Major histocompatibility complex variation and the evolution of resistance to amphibian chytridiomycosis

M Fu, B Waldman - Immunogenetics, 2017 - Springer
Chytridiomycosis, caused by the fungal pathogen Batrachochytrium dendrobatidis (Bd), has
been implicated in population declines and species extinctions of amphibians around the …

Conserved evolution of MHC supertypes among Japanese frogs suggests selection for Bd resistance

Q Lau, T Igawa, TA Kosch, AB Dharmayanthi, L Berger… - Animals, 2023 - mdpi.com
Simple Summary This study explored the major histocompatibility complex (MHC) of a
variety of Japanese frog species, to further understand why they may have resistance to the …

High functional allelic diversity and copy number in both MHC classes in the common buzzard

J Winternitz, N Chakarov, T Rinaud… - BMC Ecology and …, 2023 - Springer
Background The major histocompatibility complex (MHC), which encodes molecules that
recognize various pathogens and parasites and initiates the adaptive immune response in …

[HTML][HTML] Evolutionary analysis of major histocompatibility complex variants in chytrid-resistant and susceptible amphibians

M Fu - Infection, Genetics and Evolution, 2024 - Elsevier
An amphibian emerging infectious disease (EID), chytridiomycosis, caused by
Batrachochytrium dendrobatidis (Bd), originated in Asia but primarily led to declines and …

[HTML][HTML] Moderate Genetic Diversity of MHC Genes in an Isolated Small Population of Black-and-White Snub-Nosed Monkeys (Rhinopithecus bieti)

J Yan, C Song, J Liang, Y La, J Lai, R Pan, Z Huang… - Animals, 2024 - mdpi.com
Simple Summary Genetic diversity plays a crucial role in determining the ability of
populations to evolve. We investigated the genetic variation of the black-and-white snub …

Multiple major histocompatibility complex class I genes in Asian anurans: Ontogeny and phylogeny

C Didinger, JA Eimes, M Lillie, B Waldman - Developmental & Comparative …, 2017 - Elsevier
Amphibians, as the first terrestrial vertebrates, offer a window into early major
histocompatibility complex (MHC) evolution. We characterized the MHC class I of two …

Selective constraint acting on TLR2 and TLR4 genes of Japanese Rana frogs

Q Lau, T Igawa, TA Kosch, Y Satta - PeerJ, 2018 - peerj.com
Toll-like receptors (TLRs) are an important component of innate immunity, the first line of
pathogen defence. One of the major roles of TLRs includes recognition of pathogen …

Transcriptome analyses of immune tissues from three Japanese frogs (genus Rana ) reveals their utility in characterizing major histocompatibility complex …

Q Lau, T Igawa, R Minei, TA Kosch, Y Satta - BMC genomics, 2017 - Springer
Abstract Background In Japan and East Asia, endemic frogs appear to be tolerant or not
susceptible to chytridiomycosis, a deadly amphibian disease caused by the chytrid fungus …

Expression changes of MHC and other immune genes in frog skin during ontogeny

Q Lau, T Igawa, S Komaki, Y Satta - Animals, 2020 - mdpi.com
Simple Summary Tadpoles undergo many changes in physiology and immunology until
metamorphosis into adult frogs. Major histocompatibility complex (MHC) molecules are an …

The MHC Class Ia Genes in Chenfu's Treefrog (Zhangixalus chenfui) Evolved via Gene Duplication, Recombination, and Selection

H Chen, S Huang, Y Jiang, F Han, Q Ni, Y Yao, H Xu… - Animals, 2019 - mdpi.com
Simple Summary Amphibians, the first terrestrial vertebrates, provide materials for adaptive
evolutionary studies, such as the evolution of the major histocompatibility complex (MHC) …