Metallodrugs in cancer nanomedicine
Metal complexes are extensively used for cancer therapy. The multiple variables available
for tuning (metal, ligand, and metal–ligand interaction) offer unique opportunities for drug …
for tuning (metal, ligand, and metal–ligand interaction) offer unique opportunities for drug …
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
L Galluzzi, I Vitale, SA Aaronson, JM Abrams… - Cell Death & …, 2018 - nature.com
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …
guidelines for the definition and interpretation of cell death from morphological, biochemical …
Microbiota: a key orchestrator of cancer therapy
S Roy, G Trinchieri - Nature Reviews Cancer, 2017 - nature.com
The microbiota is composed of commensal bacteria and other microorganisms that live on
the epithelial barriers of the host. The commensal microbiota is important for the health and …
the epithelial barriers of the host. The commensal microbiota is important for the health and …
Circular RNA AKT3 upregulates PIK3R1 to enhance cisplatin resistance in gastric cancer via miR-198 suppression
Background Cisplatin (CDDP) treatment is one of the most predominant chemotherapeutic
strategies for patients with gastric cancer (GC). A better understanding of the mechanisms of …
strategies for patients with gastric cancer (GC). A better understanding of the mechanisms of …
[HTML][HTML] Battling chemoresistance in cancer: root causes and strategies to uproot them
With nearly 10 million deaths, cancer is the leading cause of mortality worldwide. Along with
major key parameters that control cancer treatment management, such as diagnosis …
major key parameters that control cancer treatment management, such as diagnosis …
Consensus guidelines for the detection of immunogenic cell death
O Kepp, L Senovilla, I Vitale, E Vacchelli… - …, 2014 - Taylor & Francis
Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit
immune responses specific for dead cell-associated antigens. However, multiple stimuli can …
immune responses specific for dead cell-associated antigens. However, multiple stimuli can …
The role of epithelial-to-mesenchymal plasticity in ovarian cancer progression and therapy resistance
Ovarian cancer is the most lethal of all gynecologic malignancies and the eighth leading
cause of cancer-related deaths among women worldwide. The main reasons for this poor …
cause of cancer-related deaths among women worldwide. The main reasons for this poor …
Molecular mechanisms for tumour resistance to chemotherapy
ST Pan, ZL Li, ZX He, JX Qiu… - Clinical and Experimental …, 2016 - Wiley Online Library
Chemotherapy is one of the prevailing methods used to treat malignant tumours, but the
outcome and prognosis of tumour patients are not optimistic. Cancer cells gradually …
outcome and prognosis of tumour patients are not optimistic. Cancer cells gradually …
Platinum resistance in ovarian cancer: role of DNA repair
G Damia, M Broggini - Cancers, 2019 - mdpi.com
Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. It is initially
responsive to cisplatin and carboplatin, two DNA damaging agents used in first line therapy …
responsive to cisplatin and carboplatin, two DNA damaging agents used in first line therapy …
Molecular mechanisms of cisplatin resistance in cervical cancer
H Zhu, H Luo, W Zhang, Z Shen, X Hu… - Drug design …, 2016 - Taylor & Francis
Patients with advanced or recurrent cervical cancer have poor prognosis, and their 1-year
survival is only 10%–20%. Chemotherapy is considered as the standard treatment for …
survival is only 10%–20%. Chemotherapy is considered as the standard treatment for …