For decades, a wide variety of natural and synthetic materials have been used to augment
human tissue to improve aesthetic outcomes. Dermal fillers are some of the most widely …

The extracellular matrix (ECM) establishes the basis for the cell's microenvironment
providing structural and mechanical support to cells and tissues, and regulating multiple cell …

The behavior of cancer cells is strongly influenced by the properties of extracellular
microenvironments, including topology, mechanics and composition. As topological and …

Type I collagen is a fibrillar protein, a member of a large family of collagen proteins. It is
present in most body tissues, usually in combination with other collagens and other …

Pathogens face varying microenvironments in vivo, but suitable experimental systems and
analysis tools to dissect how three-dimensional (3D) tissue environments impact pathogen …

Three-dimensional (3D) culture systems such as cell-laden hydrogels are superior to
standard two-dimensional (2D) monolayer cultures for many drug-screening applications …

Background Wound contraction and re-epithelialization over the entire healing process had
never been histologically examined daily in diabetic mouse wounds. Correlating …

The fibroblast-populated three-dimensional (3-D) collagen matrix has been used to model
matrix contraction, cell motility, and general fibroblast biology. MCPIP1 (monocyte …

The differences between oral mucosa and skin wound healing involving hypoxic responses
of fibroblasts are poorly elucidated. In this study, we aimed to study the different hypoxic …

The placental tissue, due to its angiogenic, anti-inflammatory, antioxidative, antimicrobial,
and anti-fibrotic properties, has become a compelling source towards a solution for several …