With the advent of effective tools to study lipids, including mass spectrometry-based
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …

Many human diseases, including metabolic, immune and central nervous system disorders,
as well as cancer, are the consequence of an alteration in lipid metabolic enzymes and their …

Purpose: Radiotherapy is a highly effective anticancer treatment forming part of the standard
of care for the majority of patients, but local and distal disease recurrence remains a major …

The discovery of fingolimod (FTY720/Gilenya; Novartis), an orally active immunomodulatory
drug, has opened up new approaches to the treatment of multiple sclerosis, the most …

Angiogenesis is a complex morphogenetic process whereby endothelial cells from existing
vessels invade as multicellular sprouts to form new vessels. Here, we have engineered a …

There is substantial evidence that sphingosine 1-phosphate (S1P) is involved in cancer.
S1P regulates processes such as inflammation, which can drive tumorigenesis; …

Angiogenic sprouting, the growth of new blood vessels from pre-existing vessels, is
orchestrated by cues from within the cellular microenvironment, such as biochemical …

Summary Protein phosphatase 2A (PP2A), one of the main serine–threonine phosphatases
in mammalian cells, maintains cell homoeostasis by counteracting most of the kinase-driven …

Lysophosphatidic acid (LPA) is a small, ubiquitous phospholipid that acts as an extracellular
signaling molecule by binding to and activating at least five known G protein–coupled …

Although obesity with associated inflammation is now recognized as a risk factor for breast
cancer and distant metastases, the functional basis for these connections remain poorly …