T-helper 17 (Th17) cells represent a subpopulation of CD4+ T lymphocytes that play an
essential role in defense against pathogens. Th17 cells are distinguished from Th1 and Th2 …

Inflammasomes are multiprotein complexes tasked with sensing endogenous or exogenous
inflammatory signals and integrating this signal into a downstream response. Inflammasome …

Rationale: Tolerogenic dendritic cells (tol-DCs) play essential roles in immune-related
diseases and induce immune tolerance by shaping T-cell responses. Accumulating …

Background Moderate-to-severe atopic dermatitis (AD) has been associated with significant
disease burden and systemic abnormalities and often requires systemic treatments …

Background ASN002 is an oral dual inhibitor of Janus kinase and spleen tyrosine kinase,
which are involved in the pathogenesis of atopic dermatitis (AD) through their regulatory role …

Janus kinases (JAKs) are the non-receptor tyrosine kinases covering JAK1, JAK2, JAK3,
and TYK2 which regulate signal transductions of hematopoietic cytokines and growth factors …

NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is a
cytoplasmic multiprotein complex composed of the innate immune receptor protein NLRP3 …

Abstract Purpose of Review Bronchial asthma is a common respiratory disease induced by
immune imbalance, characterized by chronic non-specific airway inflammation and airway …

Apical periodontitis is an inflammatory condition that is considered an immunological
reaction of the periapical tissue to invading bacteria and their pathogenic components …

Maintenance of immune homeostasis is an intricate process wherein inflammasomes play a
pivotal role by contributing to innate and adaptive immune responses. Inflammasomes are …