The life cycles of many parasites involve transitions between disparate host species,
requiring these parasites to go through multiple developmental stages adapted to each of …

Organisms with identical genome sequences can show substantial differences in their
phenotypes owing to epigenetic changes that result in different use of their genes …

Plasmodium falciparum remains the deadliest parasite species in the world, responsible for
229 million cases of human malaria in 2019. The ability of the P. falciparum parasite to …

Human to vector transmission of malaria requires that some blood-stage parasites abandon
asexual growth and convert into non-replicating sexual forms called gametocytes. The initial …

Periodic fever is a characteristic clinical feature of human malaria, but how parasites survive
febrile episodes is not known. Although the genomes of Plasmodium species encode a full …

Background The human malaria parasite Plasmodium falciparum has a complex and multi-
stage life cycle that requires extensive and precise gene regulation to allow invasion and …

Malaria genetic variation has been extensively characterized, but the level of epigenetic
plasticity remains largely unexplored. Here we provide a comprehensive characterization of …

Obligate intracellular parasites must efficiently invade host cells in order to mature and be
transmitted. For the malaria parasite Plasmodium falciparum, invasion of host red blood cells …

Acquired immunity in vertebrates maintains polymorphisms in endemic pathogens, leading
to identifiable signatures of balancing selection. To comprehensively survey for genes under …

During red-blood-cell-stage infection of Plasmodium falciparum, the parasite undergoes
repeated rounds of replication, egress, and invasion. Erythrocyte invasion involves specific …