FDA-approved pyrimidine-fused bicyclic heterocycles for cancer therapy: Synthesis and clinical application

S Wang, XH Yuan, SQ Wang, W Zhao, XB Chen… - European Journal of …, 2021 - Elsevier
Considerable progress has been made in the development of anticancer agents over the
past few decades, and a lot of new anticancer agents from natural and synthetic sources …

Natural products targeting tumour angiogenesis

X Lu, LJ Friedrich, T Efferth - British journal of pharmacology, 2023 - Wiley Online Library
Tumour angiogenesis is the formation of new blood vessels to support the growth of a
tumour. This process is critical for tumour progression and metastasis, making it an attractive …

Emerging applications of anti-angiogenic nanomaterials in oncotherapy

B Tang, W Ma, Y Lin - Journal of Controlled Release, 2023 - Elsevier
Angiogenesis is the process of generating new blood vessels from pre-existing vasculature.
Under normal conditions, this process is delicately controlled by pro-angiogenic and anti …

An appraisal of anticancer activity with structure–activity relationship of quinazoline and quinazolinone analogues through EGFR and VEGFR inhibition: A review

K Haider, S Das, A Joseph… - Drug Development …, 2022 - Wiley Online Library
Cancer is one of the leading causes of death. Globally a huge number of deaths and new
incidences are reported annually. Heterocyclic compounds have been proved to be very …

Thyroid cancer in the age of COVID-19

VHM Tsang, M Gild, A Glover… - Endocrine-Related …, 2020 - erc.bioscientifica.com
COVID-19 has modified the way we practice medicine. For thyroid cancer, there have been
several significant impacts. First, the diagnosis has been delayed due to social isolation …

Recent advances of anti-angiogenic inhibitors targeting VEGF/VEGFR axis

L Wang, WQ Liu, S Broussy, B Han… - Frontiers in …, 2024 - frontiersin.org
Vascular endothelial growth factors (VEGF), Vascular endothelial growth factor receptors
(VEGFR) and their downstream signaling pathways are promising targets in anti-angiogenic …

Novel therapeutic clues in thyroid carcinomas: the role of targeting cancer stem cells

A Antonelli, C La Motta - Medicinal Research Reviews, 2017 - Wiley Online Library
Thyroid carcinomas (TCs), the most common endocrine tumors, represent the eighth most
common cancer diagnosed worldwide in both women and men. To treat these malignancies …

[HTML][HTML] Preparation and characterisation of vandetanib-eluting radiopaque beads for locoregional treatment of hepatic malignancies

A Hagan, GJ Phillips, WM Macfarlane, AW Lloyd… - European Journal of …, 2017 - Elsevier
Since their introduction around a decade ago, embolic drug-eluting beads (DEBs) have
become a well-established treatment option for the locoregional transarterial treatment of …

Anticancer Biological Profile of Some Heterocylic Moieties-Thiadiazole, Benzimidazole, Quinazoline, and Pyrimidine

PS Sidat, TMK Jaber, SR Vekariya… - …, 2022 - pharmacophorejournal.com
Cancer is a disease characterized by genetic or epigenetic alterations in somatic cells that
result in uncontrolled cell growth and spread to other regions of the body. They are one type …

Daily Management of patients on multikinase inhibitors' treatment

C Colombo, S De Leo, M Trevisan, N Giancola… - Frontiers in …, 2022 - frontiersin.org
In a minority of differentiated thyroid cancer (TC) cases and in a large percentage of poorly
differentiated TCs (PDTCs) and anaplastic TCs (ATCs), the prognosis is poor due to the lack …