Eg5, the product of Kif11 gene, also known as kinesin spindle protein, is a motor protein
involved in the proper establishment of a bipolar mitotic spindle. Eg5 is one of the 45 …

Kinesins are a diverse superfamily of microtubule-based motors that perform fundamental
roles in intracellular transport, cytoskeletal dynamics and cell division. These motors share a …

Kinesin-1 is an ATP-driven, processive motor that transports cargo along microtubules in a
tightly regulated stepping cycle. Efficient gating mechanisms ensure that the sequence of …

Several kinesin-5 motors (kinesin-5s) exhibit bidirectional motility. The mechanism of such
motility remains unknown. Bidirectional kinesin-5s share a long N-terminal nonmotor …

Kinesins and myosins hydrolyze ATP, producing force that drives spindle assembly, vesicle
transport and muscle contraction. How do motors do this? Here we discuss mechanisms of …

Kinesin proteins are critical for various cellular functions such as intracellular transport and
cell division, and many members of the family have been linked to monogenic disorders and …

Kinesin-5 is required for forming the bipolar spindle during mitosis. Its motor domain, which
contains nucleotide and microtubule binding sites and mechanical elements to generate …

Eg5 is a kinesin motor protein that is responsible for bipolar spindle formation and plays a
crucial role during mitosis. Loss of Eg5 function leads to the formation of monopolar …

Homodimeric KIF17 and heterotrimeric KIF3AB are processive, kinesin-2 family motors that
act jointly to carry out anterograde intraflagellar transport (IFT), ferrying cargo along …

Kinesins are responsible for a wide variety of microtubule-based, ATP-dependent functions.
Their motor domain drives these activities, but the molecular adaptations that specify these …