[HTML][HTML] Synthesis and biological evaluation of orally active anti-Trypanosoma agents

FM Salem, WR Martin, X Zhao, SKA Sayeed… - Bioorganic & Medicinal …, 2024 - Elsevier
In previous studies, we developed anti-trypanosome tubulin inhibitors with promising in vitro
selectivity and activity against Human African Trypanosomiasis (HAT). However, for such …

化学蛋白质组学在天然产物分子靶标鉴定中的应用.

璐祺, 崔婷茹, 郝楠, 赵雨薇, 赵斌… - Biotechnology …, 2023 - search.ebscohost.com
绿色新农药的开发和利用有利于农业的可持续发展, 基于天然产物进行活性先导发现及作用机制
研究是重要的新农药创制策略, 然而其作用靶标和作用机制难以确定, 阻碍了其在新农药中的 …