Cancer therapy is a significant challenge due to insufficient drug delivery to the cancer cells
and non-selective killing of healthy cells by most chemotherapy agents. Nano-formulations …

High-density lipoproteins (HDL) are endogenous nanoparticles involved in the transport and
metabolism of cholesterol, phospholipids, and triglycerides. HDL is well-known as the …

Glioblastoma multiforme (GBM) is an aggressive primary brain tumor, for which there is no
cure. Treatment effectiveness for GBM has been limited due to tumor heterogeneity, an …

Prodrug nanoassemblies have emerged as a promising platform for the delivery of
anticancer drugs. PEGylation is a “gold standard” to improve colloidal stability and …

One of biology's most pervasive nanostructures, the phospholipid membrane, represents an
ideal scaffold for a host of nanotechnology applications. Whether engineering biomimetic …

Carrier-free, functionalized drug nanoparticles for targeted drug delivery - Chemical
Communications (RSC Publishing) DOI:10.1039/C2CC33214K Royal Society of Chemistry …

Apolipoproteins are critical structural and functional components of lipoproteins, which are
large supramolecular assemblies composed predominantly of lipids and proteins, and other …

Disease heterogeneity within and between patients necessitates a patient-focused
approach to cancer treatment. This exigency forms the basis for the medical practice termed …

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy and has a 5-year survival
rate of< 35%. ACC cells require cholesterol for steroid hormone production, and this …

Many drugs have decreased therapeutic activity due to issues with absorption, distribution,
metabolism and excretion. The co-formulation or covalent attachment of drugs with fatty …