Pathogenesis of chronic obstructive pulmonary disease: understanding the contributions of gene–environment interactions across the lifespan
The traditional view of chronic obstructive pulmonary disease (COPD) as a self-inflicted
disease caused by tobacco smoking in genetically susceptible individuals has been …
disease caused by tobacco smoking in genetically susceptible individuals has been …
DNA methylation-based predictors of health: applications and statistical considerations
DNA methylation data have become a valuable source of information for biomarker
development, because, unlike static genetic risk estimates, DNA methylation varies …
development, because, unlike static genetic risk estimates, DNA methylation varies …
Evaluating intrinsic and non-intrinsic cancer risk factors
Discriminating the contribution of unmodifiable random intrinsic DNA replication errors ('bad
luck') to cancer development from those of other factors is critical for understanding cancer in …
luck') to cancer development from those of other factors is critical for understanding cancer in …
Epigenetic signatures of cigarette smoking
Background—DNA methylation leaves a long-term signature of smoking exposure and is
one potential mechanism by which tobacco exposure predisposes to adverse health …
one potential mechanism by which tobacco exposure predisposes to adverse health …
DNA methylation in newborns and maternal smoking in pregnancy: genome-wide consortium meta-analysis
Epigenetic modifications, including DNA methylation, represent a potential mechanism for
environmental impacts on human disease. Maternal smoking in pregnancy remains an …
environmental impacts on human disease. Maternal smoking in pregnancy remains an …
Environmental risk factors of type 2 diabetes—An exposome approach
Type 2 diabetes is one of the major chronic diseases accounting for a substantial proportion
of disease burden in Western countries. The majority of the burden of type 2 diabetes is …
of disease burden in Western countries. The majority of the burden of type 2 diabetes is …
[HTML][HTML] What is new in the exposome?
P Vineis, O Robinson, M Chadeau-Hyam… - Environment …, 2020 - Elsevier
The exposome concept refers to the totality of exposures from a variety of external and
internal sources including chemical agents, biological agents, or radiation, from conception …
internal sources including chemical agents, biological agents, or radiation, from conception …
DNA methylation signatures in peripheral blood strongly predict all-cause mortality
Y Zhang, R Wilson, J Heiss, LP Breitling… - Nature …, 2017 - nature.com
DNA methylation (DNAm) has been revealed to play a role in various diseases. Here we
performed epigenome-wide screening and validation to identify mortality-related DNAm …
performed epigenome-wide screening and validation to identify mortality-related DNAm …
DNA methylation‐based biomarkers of aging were slowed down in a two‐year diet and physical activity intervention trial: The DAMA study
Several biomarkers of healthy aging have been proposed in recent years, including the
epigenetic clocks, based on DNA methylation (DNAm) measures, which are getting …
epigenetic clocks, based on DNA methylation (DNAm) measures, which are getting …
Genetic and environmental influences interact with age and sex in shaping the human methylome
The methylome is subject to genetic and environmental effects. Their impact may depend on
sex and age, resulting in sex-and age-related physiological variation and disease …
sex and age, resulting in sex-and age-related physiological variation and disease …