Biomolecular condensates, membrane-less entities arising from liquid–liquid phase
separation, hold dichotomous roles in health and disease. Alongside their physiological …

Simple Summary The transcription factor p53 is a crucial tumor suppressor that regulates
diverse cellular responses to protect against cancer development. Deactivating p53 …

Amid the complexity of genetic alterations in human cancer, TP53 mutation appears as an
almost invariant component, representing by far the most frequent genetic alteration overall …

In this review we focus on the major isoforms of the tumor-suppressor protein p53,
dysfunction of which often leads to cancer. Mutations of the TP53 gene, particularly in the …

Gliomas are heterogeneous tumours derived from glial cells and remain the deadliest form
of brain cancer. Although the glioma stem cell sits at the apex of the cellular hierarchy, how it …

The p53 family of proteins evolved from a common ancestor into three separate genes
encoding proteins that act as transcription factors with distinct cellular roles. Isoforms of each …

Breast cancer (BC) is characterized by an extensive genotypic and phenotypic
heterogeneity. In-depth investigations into the molecular bases of BC phenotypes …

The p53 transcription factor confers its potent tumor suppressor functions primarily through
the regulation of a large network of target genes. The recent explosion of next generation …

TP53 is a tumor suppressor gene that encodes a sequence-specific DNA-binding
transcription factor activated by stressful stimuli; it upregulates target genes involved in …

Simple Summary The well-known tumor suppressor protein p53 plays important roles in
tumor prevention through transcriptional regulation of its target genes. Reactivation of p53 …