[HTML][HTML] The role of vaccines in combatting antimicrobial resistance
F Micoli, F Bagnoli, R Rappuoli, D Serruto - Nature Reviews …, 2021 - nature.com
The use of antibiotics has enabled the successful treatment of bacterial infections, saving the
lives and improving the health of many patients worldwide. However, the emergence and …
lives and improving the health of many patients worldwide. However, the emergence and …
A brief review on Group A Streptococcus pathogenesis and vaccine development
SA Castro, HC Dorfmueller - Royal Society open science, 2021 - royalsocietypublishing.org
Streptococcus pyogenes, also known as Group A Streptococcus (GAS), is a Gram-positive
human-exclusive pathogen, responsible for more than 500 000 deaths annually worldwide …
human-exclusive pathogen, responsible for more than 500 000 deaths annually worldwide …
[HTML][HTML] Status of research and development of vaccines for Streptococcus pyogenes
Streptococcus pyogenes is an important global pathogen, causing considerable morbidity
and mortality, especially in low and middle income countries where rheumatic heart disease …
and mortality, especially in low and middle income countries where rheumatic heart disease …
A Glycolipidated-liposomal peptide vaccine confers long-term mucosal protection against Streptococcus pyogenes via IL-17, macrophages and neutrophils
Mucosally active subunit vaccines are an unmet clinical need due to lack of licensed
immunostimulants suitable for vaccine antigens. Here, we show that intranasal …
immunostimulants suitable for vaccine antigens. Here, we show that intranasal …
Rheumatic heart disease: a review of the current status of global research activity
Rheumatic heart disease (RHD) is a serious and long-term consequence of acute rheumatic
fever (ARF), an autoimmune sequela of a mucosal infection by Streptococcus pyogenes …
fever (ARF), an autoimmune sequela of a mucosal infection by Streptococcus pyogenes …
Streptococcus pyogenes: Pathogenesis and the Current Status of Vaccines
J Wang, C Ma, M Li, X Gao, H Wu, W Dong, L Wei - Vaccines, 2023 - mdpi.com
Streptococcus pyogenes (group A Streptococcus; GAS), a Gram-positive coccal bacterium,
poses a significant global disease burden, especially in low-and middle-income countries …
poses a significant global disease burden, especially in low-and middle-income countries …
Evaluation of safety and immunogenicity of a group A streptococcus vaccine candidate (MJ8VAX) in a randomized clinical trial
Background Group A streptococcus (GAS) is a serious human pathogen that affects people
of different ages and socio-economic levels. Although vaccination is potentially one of the …
of different ages and socio-economic levels. Although vaccination is potentially one of the …
Recent advances in the rheumatic fever and rheumatic heart disease continuum
J Rwebembera, BR Nascimento, NW Minja… - Pathogens, 2022 - mdpi.com
Nearly a century after rheumatic fever (RF) and rheumatic heart disease (RHD) was
eradicated from the developed world, the disease remains endemic in many low-and middle …
eradicated from the developed world, the disease remains endemic in many low-and middle …
Chemical synergy between ionophore PBT2 and zinc reverses antibiotic resistance
ABSTRACT The World Health Organization reports that antibiotic-resistant pathogens
represent an imminent global health disaster for the 21st century. Gram-positive superbugs …
represent an imminent global health disaster for the 21st century. Gram-positive superbugs …
Complement inhibition by Sarcoptes scabiei protects Streptococcus pyogenes-An in vitro study to unravel the molecular mechanisms behind the poorly understood …
PM Swe, LD Christian, HC Lu… - PLoS neglected …, 2017 - journals.plos.org
Background On a global scale scabies is one of the most common dermatological
conditions, imposing a considerable economic burden on individuals, communities and …
conditions, imposing a considerable economic burden on individuals, communities and …