[HTML][HTML] The role of vaccines in combatting antimicrobial resistance

F Micoli, F Bagnoli, R Rappuoli, D Serruto - Nature Reviews …, 2021 - nature.com
The use of antibiotics has enabled the successful treatment of bacterial infections, saving the
lives and improving the health of many patients worldwide. However, the emergence and …

A brief review on Group A Streptococcus pathogenesis and vaccine development

SA Castro, HC Dorfmueller - Royal Society open science, 2021 - royalsocietypublishing.org
Streptococcus pyogenes, also known as Group A Streptococcus (GAS), is a Gram-positive
human-exclusive pathogen, responsible for more than 500 000 deaths annually worldwide …

[HTML][HTML] Status of research and development of vaccines for Streptococcus pyogenes

AC Steer, JR Carapetis, JB Dale, JD Fraser, MF Good… - Vaccine, 2016 - Elsevier
Streptococcus pyogenes is an important global pathogen, causing considerable morbidity
and mortality, especially in low and middle income countries where rheumatic heart disease …

A Glycolipidated-liposomal peptide vaccine confers long-term mucosal protection against Streptococcus pyogenes via IL-17, macrophages and neutrophils

V Ozberk, M Zaman, A Lepletier, S Eskandari… - Nature …, 2023 - nature.com
Mucosally active subunit vaccines are an unmet clinical need due to lack of licensed
immunostimulants suitable for vaccine antigens. Here, we show that intranasal …

Rheumatic heart disease: a review of the current status of global research activity

LM Dooley, TB Ahmad, M Pandey, MF Good… - Autoimmunity reviews, 2021 - Elsevier
Rheumatic heart disease (RHD) is a serious and long-term consequence of acute rheumatic
fever (ARF), an autoimmune sequela of a mucosal infection by Streptococcus pyogenes …

Streptococcus pyogenes: Pathogenesis and the Current Status of Vaccines

J Wang, C Ma, M Li, X Gao, H Wu, W Dong, L Wei - Vaccines, 2023 - mdpi.com
Streptococcus pyogenes (group A Streptococcus; GAS), a Gram-positive coccal bacterium,
poses a significant global disease burden, especially in low-and middle-income countries …

Evaluation of safety and immunogenicity of a group A streptococcus vaccine candidate (MJ8VAX) in a randomized clinical trial

S Sekuloski, MR Batzloff, P Griffin, W Parsonage… - PLoS …, 2018 - journals.plos.org
Background Group A streptococcus (GAS) is a serious human pathogen that affects people
of different ages and socio-economic levels. Although vaccination is potentially one of the …

Recent advances in the rheumatic fever and rheumatic heart disease continuum

J Rwebembera, BR Nascimento, NW Minja… - Pathogens, 2022 - mdpi.com
Nearly a century after rheumatic fever (RF) and rheumatic heart disease (RHD) was
eradicated from the developed world, the disease remains endemic in many low-and middle …

Chemical synergy between ionophore PBT2 and zinc reverses antibiotic resistance

L Bohlmann, DMP De Oliveira, IM El-Deeb, EB Brazel… - MBio, 2018 - Am Soc Microbiol
ABSTRACT The World Health Organization reports that antibiotic-resistant pathogens
represent an imminent global health disaster for the 21st century. Gram-positive superbugs …

Complement inhibition by Sarcoptes scabiei protects Streptococcus pyogenes-An in vitro study to unravel the molecular mechanisms behind the poorly understood …

PM Swe, LD Christian, HC Lu… - PLoS neglected …, 2017 - journals.plos.org
Background On a global scale scabies is one of the most common dermatological
conditions, imposing a considerable economic burden on individuals, communities and …