Various frameworks and methods, such as quality by design (QbD), real time release test
(RTRT), and continuous process verification (CPV), have been introduced to improve drug …

High shear wet granulation (HSWG) is considered a complicated and multivariate
pharmaceutical process that is influenced by a large number of variables derived from …

This study investigated the effect of formulation parameters on granule properties and
growth behavior using a 16mm twin screw granulator. A model placebo formulation …

Granulation, a size enlargement technique to form agglomerates of primary particles, has
proven to be effective in the production of solid dosage forms. Numerous granulation …

The effective implementation of Quality by Design (QbD) for wet granulation requires
quantitative models for design and scaling of granulators. This paper reviews that current …

The aim of this study was to investigate the influence of qualitatively different powder feeder
performances on resulting granule size distributions after twin-screw granulation of a highly …

High-shear wet granulation is a complex process that, in turn, makes scale-up a challenging
task. Scale-up of high-shear wet granulation process has been studied extensively in the …

“T unneling,”“S preading,” and “C rater F ormation” are the three granule formation
mechanisms known to occur when single drops impact static powder beds. To quantify the …

The purpose of the current work is to study the effects of high-shear wet granulation process
parameters on granule characteristics using both experimental and modeling techniques. A …

We outline the smart manufacturing challenges for formulated products, which are typically
multicomponent, structured, and multiphase. These challenges predominate in the food …