The hormone melatonin (5-methoxy-N-acetyltryptamine) is synthesized primarily in the
pineal gland and retina, and in several peripheral tissues and organs. In the circulation, the …

The assembly of architecturally complex alkaloids embedding the indole nucleus is of
paramount importance for the target oriented synthesis of biologically active molecules. 1 A …

Numerous physiological functions of the pineal gland hormone melatonin are mediated via
activation of two G-protein-coupled receptors, MT1 and MT2. The melatonergic drugs on the …

A new strategy for the catalytic synthesis of substituted 1 H-indenes via metalloradical
activation of o-cinnamyl N-tosyl hydrazones is presented, taking advantage of the intrinsic …

6 H-Isoindolo [2, 1-a] indoles (5, 7, 10, 13), 5, 6-dihydroindolo [2, 1-a] isoquinolines (20, 21),
and 6, 7-dihydro-5 H-benzo [c] azepino [2, 1-a] indoles (23, 25, 27, 30) have been prepared …

Highly enantioselective hydrogenation of 3-(α-hydroxyalkyl) indoles promoted by a Brønsted
acid for dehydration to form a vinylogous iminium intermediate in situ was developed with …

Melatonin MT1 and MT2 receptor ligands have been vigorously explored for the last 4
decades. Inspection of approximately 80 publications in the field revealed that most …

Melatonin is a natural hormone primarily released by the pineal gland that regulates the
sleep-wake cycles. The diverse biological applications of melatonin, together with the need …

In this review we summarized the actual clinical data for a cardioprotective therapeutic role
of melatonin, listed melatonin and its agonists in different stages of development, and …

Monoamine oxidase B (MAO-B) metabolizes dopamine and plays an important role in
oxidative stress by altering the redox state of neuronal and glial cells. MAO-B inhibitors are a …