N6-methyladenosine RNA modification in inflammation: roles, mechanisms, and applications
J Luo, T Xu, K Sun - Frontiers in cell and developmental biology, 2021 - frontiersin.org
N6-methyladenosine (m6A) is the most prevalent internal mRNA modification. m6A can be
installed by the methyltransferase complex and removed by demethylases, which are …
installed by the methyltransferase complex and removed by demethylases, which are …
A critical review of novel antibiotic resistance prevention approaches with a focus on postbiotics
Antibiotic resistance is a significant public health issue, causing illnesses that were once
easily treatable with antibiotics to develop into dangerous infections, leading to substantial …
easily treatable with antibiotics to develop into dangerous infections, leading to substantial …
METTL3-m6A-EGFR-axis drives lenvatinib resistance in hepatocellular carcinoma
L Wang, Q Yang, Q Zhou, F Fang, K Lei, Z Liu, G Zheng… - Cancer letters, 2023 - Elsevier
Lenvatinib is emerging as the first-line therapeutic option for advanced hepatocellular
carcinoma (HCC), but drug resistance remains a major hurdle for its long-term therapy …
carcinoma (HCC), but drug resistance remains a major hurdle for its long-term therapy …
piRNA-14633 promotes cervical cancer cell malignancy in a METTL14-dependent m6A RNA methylation manner
Q Xie, Z Li, X Luo, D Wang, Y Zhou, J Zhao… - Journal of translational …, 2022 - Springer
Background Cervical cancer (CC) is one of the most common gynecological tumors that
threatens women's health and lives. Aberrant expression of PIWI-interacting RNA (piRNA) is …
threatens women's health and lives. Aberrant expression of PIWI-interacting RNA (piRNA) is …
[HTML][HTML] m6A demethylase FTO renders radioresistance of nasopharyngeal carcinoma via promoting OTUB1-mediated anti-ferroptosis
WM Huang, ZX Li, YH Wu, ZL Shi, JL Mi, K Hu… - Translational …, 2023 - Elsevier
Radiotherapy is a valid treatment for nasopharyngeal carcinoma (NPC), and radioresistance
is the main cause of local NPC treatment failure. However, the underlying mechanisms and …
is the main cause of local NPC treatment failure. However, the underlying mechanisms and …
[HTML][HTML] m6A modification in inflammatory bowel disease provides new insights into clinical applications
J Zhang, B Song, Y Zeng, C Xu, L Gao, Y Guo… - Biomedicine & …, 2023 - Elsevier
Inflammatory bowel disease (IBD) results from a complex interplay between genetic
predisposition, environmental factors, and gut microbes. The role of N6-methyladenosine …
predisposition, environmental factors, and gut microbes. The role of N6-methyladenosine …
YTHDC1 m6A-dependent and m6A-independent functions converge to preserve the DNA damage response
D Elvira-Blázquez, JM Fernández-Justel… - The EMBO …, 2024 - embopress.org
Cells have evolved a robust and highly regulated DNA damage response to preserve their
genomic integrity. Although increasing evidence highlights the relevance of RNA regulation …
genomic integrity. Although increasing evidence highlights the relevance of RNA regulation …
RNA demethylase ALKBH5 regulates hypopharyngeal squamous cell carcinoma ferroptosis by posttranscriptionally activating NFE2L2/NRF2 in an m6A‐IGF2BP2 …
J Ye, X Chen, X Jiang, Z Dong, S Hu… - Journal of Clinical …, 2022 - Wiley Online Library
Background Having emerged as the most abundant posttranscriptional internal mRNA
modification in eukaryotes, N6‐methyladenosine (m6A) has attracted tremendous scientific …
modification in eukaryotes, N6‐methyladenosine (m6A) has attracted tremendous scientific …
Roles and implications of mRNA N6‐methyladenosine in cancer
RNA N6‐methyladenosine modification is the most prevalent internal modification of
eukaryotic RNAs and has emerged as a novel field of RNA epigenetics, garnering increased …
eukaryotic RNAs and has emerged as a novel field of RNA epigenetics, garnering increased …
N6-methyladenosine modification of the 5′ epsilon structure of the HBV pregenome RNA regulates its encapsidation by the viral core protein
GW Kim, JS Moon, A Siddiqui - Proceedings of the National …, 2022 - National Acad Sciences
Hepatitis B virus (HBV) contains a partially double-stranded DNA genome. During infection,
its replication is mediated by reverse transcription (RT) of an RNA intermediate termed …
its replication is mediated by reverse transcription (RT) of an RNA intermediate termed …