Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials

X Xie, T Yu, X Li, N Zhang, LJ Foster, C Peng… - Signal transduction and …, 2023 - nature.com
Undruggable proteins are a class of proteins that are often characterized by large, complex
structures or functions that are difficult to interfere with using conventional drug design …

Targeting the epigenetic regulation of antitumour immunity

SJ Hogg, PA Beavis, MA Dawson… - Nature reviews Drug …, 2020 - nature.com
Dysregulation of the epigenome drives aberrant transcriptional programmes that promote
cancer onset and progression. Although defective gene regulation often affects oncogenic …

[HTML][HTML] KRASG12C Inhibition with Sotorasib in Advanced Solid Tumors

DS Hong, MG Fakih, JH Strickler, J Desai… - … England Journal of …, 2020 - Mass Medical Soc
Background No therapies for targeting KRAS mutations in cancer have been approved. The
KRAS p. G12C mutation occurs in 13% of non–small-cell lung cancers (NSCLCs) and in 1 to …

Artificial intelligence in cancer target identification and drug discovery

Y You, X Lai, Y Pan, H Zheng, J Vera, S Liu… - … and Targeted Therapy, 2022 - nature.com
Artificial intelligence is an advanced method to identify novel anticancer targets and discover
novel drugs from biology networks because the networks can effectively preserve and …

Targeting aberrant RAS/RAF/MEK/ERK signaling for cancer therapy

U Degirmenci, M Wang, J Hu - Cells, 2020 - mdpi.com
The RAS/RAF/MEK/ERK (MAPK) signaling cascade is essential for cell inter-and intra-
cellular communication, which regulates fundamental cell functions such as growth, survival …

Role of cadherins in cancer—a review

I Kaszak, O Witkowska-Piłaszewicz… - International journal of …, 2020 - mdpi.com
Cadherins play an important role in tissue homeostasis, as they are responsible for cell-cell
adhesion during embryogenesis, tissue morphogenesis, differentiation and carcinogenesis …

RAF-MEK-ERK pathway in cancer evolution and treatment

R Ullah, Q Yin, AH Snell, L Wan - Seminars in cancer biology, 2022 - Elsevier
Abstract The RAF-MEK-ERK signaling cascade is a well-characterized MAPK pathway
involved in cell proliferation and survival. The three-layered MAPK signaling cascade is …

Molecular subtypes of pancreatic cancer

EA Collisson, P Bailey, DK Chang… - Nature reviews …, 2019 - nature.com
Cancers that appear morphologically similar often have dramatically different clinical
features, respond variably to therapy and have a range of outcomes. Compelling evidence …

mTOR signaling in cancer and mTOR inhibitors in solid tumor targeting therapy

T Tian, X Li, J Zhang - International journal of molecular sciences, 2019 - mdpi.com
The mammalian or mechanistic target of rapamycin (mTOR) pathway plays a crucial role in
regulation of cell survival, metabolism, growth and protein synthesis in response to upstream …

Comprehensive molecular characterization of muscle-invasive bladder cancer

AG Robertson, J Kim, H Al-Ahmadie, J Bellmunt, G Guo… - Cell, 2017 - cell.com
We report a comprehensive analysis of 412 muscle-invasive bladder cancers characterized
by multiple TCGA analytical platforms. Fifty-eight genes were significantly mutated, and the …