Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials
Undruggable proteins are a class of proteins that are often characterized by large, complex
structures or functions that are difficult to interfere with using conventional drug design …
structures or functions that are difficult to interfere with using conventional drug design …
Targeting the epigenetic regulation of antitumour immunity
Dysregulation of the epigenome drives aberrant transcriptional programmes that promote
cancer onset and progression. Although defective gene regulation often affects oncogenic …
cancer onset and progression. Although defective gene regulation often affects oncogenic …
[HTML][HTML] KRASG12C Inhibition with Sotorasib in Advanced Solid Tumors
Background No therapies for targeting KRAS mutations in cancer have been approved. The
KRAS p. G12C mutation occurs in 13% of non–small-cell lung cancers (NSCLCs) and in 1 to …
KRAS p. G12C mutation occurs in 13% of non–small-cell lung cancers (NSCLCs) and in 1 to …
Artificial intelligence in cancer target identification and drug discovery
Artificial intelligence is an advanced method to identify novel anticancer targets and discover
novel drugs from biology networks because the networks can effectively preserve and …
novel drugs from biology networks because the networks can effectively preserve and …
Targeting aberrant RAS/RAF/MEK/ERK signaling for cancer therapy
U Degirmenci, M Wang, J Hu - Cells, 2020 - mdpi.com
The RAS/RAF/MEK/ERK (MAPK) signaling cascade is essential for cell inter-and intra-
cellular communication, which regulates fundamental cell functions such as growth, survival …
cellular communication, which regulates fundamental cell functions such as growth, survival …
Role of cadherins in cancer—a review
I Kaszak, O Witkowska-Piłaszewicz… - International journal of …, 2020 - mdpi.com
Cadherins play an important role in tissue homeostasis, as they are responsible for cell-cell
adhesion during embryogenesis, tissue morphogenesis, differentiation and carcinogenesis …
adhesion during embryogenesis, tissue morphogenesis, differentiation and carcinogenesis …
RAF-MEK-ERK pathway in cancer evolution and treatment
Abstract The RAF-MEK-ERK signaling cascade is a well-characterized MAPK pathway
involved in cell proliferation and survival. The three-layered MAPK signaling cascade is …
involved in cell proliferation and survival. The three-layered MAPK signaling cascade is …
Molecular subtypes of pancreatic cancer
Cancers that appear morphologically similar often have dramatically different clinical
features, respond variably to therapy and have a range of outcomes. Compelling evidence …
features, respond variably to therapy and have a range of outcomes. Compelling evidence …
mTOR signaling in cancer and mTOR inhibitors in solid tumor targeting therapy
T Tian, X Li, J Zhang - International journal of molecular sciences, 2019 - mdpi.com
The mammalian or mechanistic target of rapamycin (mTOR) pathway plays a crucial role in
regulation of cell survival, metabolism, growth and protein synthesis in response to upstream …
regulation of cell survival, metabolism, growth and protein synthesis in response to upstream …
Comprehensive molecular characterization of muscle-invasive bladder cancer
We report a comprehensive analysis of 412 muscle-invasive bladder cancers characterized
by multiple TCGA analytical platforms. Fifty-eight genes were significantly mutated, and the …
by multiple TCGA analytical platforms. Fifty-eight genes were significantly mutated, and the …