Studies of families and twins show the importance of genetic factors affecting susceptibility to
bipolar disorder and suggest substantial genetic and phenotypic complexity. Robust and …

The adult form of attention deficit/hyperactivity disorder (aADHD) has a prevalence of up to
5% and is the most severe long-term outcome of this common neurodevelopmental disorder …

Background CHD8 (chromodomain helicase DNA-binding protein 8), which codes for a
member of the CHD family of ATP-dependent chromatin-remodeling factors, is one of the …

Balanced chromosomal abnormalities (BCAs) represent a relatively untapped reservoir of
single-gene disruptions in neurodevelopmental disorders (NDDs). We sequenced BCAs in …

Objective: Narcolepsy is caused by the loss of hypocretin/orexin neurons in the
hypothalamus, which is likely the result of an autoimmune process. Recently, concern has …

The panoply of cognitive, affective, motivational, and social functions that underpin everyday
human experience requires precisely choreographed patterns of interaction between …

BackgroundRecent data suggest trait-like neurocognitive impairments in bipolar disorder
(BPD), with deficits about 1 sd below average, less severe than deficits noted in …

Recent large-scale genomic studies have revealed two broad classes of risk alleles for
schizophrenia: a polygenic component of risk mediated through multiple common risk …

We have used a translational convergent functional genomics (CFG) approach to identify
and prioritize genes involved in schizophrenia, by gene-level integration of genome-wide …

Several lines of evidence suggest that genome-wide association studies (GWAS) have the
potential to explain more of the “missing heritability” of common complex phenotypes …