Traumatic-induced coagulopathy (TIC) is a hemostatic disorder that is associated with
significant bleeding, transfusion requirements, morbidity and mortality. A disorder similar or …

Introduction: Injury is the second leading cause of death worldwide, and as much as 40% of
injury-related mortality is attributed to uncontrollable hemorrhage. This persists despite …

Background Major trauma is a leading cause of morbidity and mortality worldwide with
hemorrhage accounting for 40% of deaths. Acute traumatic coagulopathy exacerbates …

Abstract Background Low fibrinogen (Fg) concentrations in trauma haemorrhage are
associated with poorer outcomes. Cryoprecipitate is the standard source for Fg …

Trauma promotes trauma‐induced coagulopathy, which requires urgent treatment with fixed‐
ratio transfusions of red blood cells, fresh frozen plasma and platelet concentrates, or goal …

Background. Decreased plasma fibrinogen concentration shortly after injury is associated
with higher blood transfusion needs and mortality. In North America and the UK …

Bleeding remains the leading cause of preventable death following injury1. Contributing to
this problem, coagulopathy develops in approximately one-third of all injured patients2-4 …

Urgent surgery or life-threatening bleeding requires prompt reversal of the anticoagulant
effects of dabigatran. This study assessed the ability of three-and four-factor prothrombin …

Background Trauma-induced coagulopathy (TIC) is common in trauma patients with major
hemorrhage. Prothrombin complex concentrate (PCC) is used as a potential treatment for …

Background Traumatic injury results in both physical and physiologic insult. Successful care
of the trauma patient depends upon timely correction of both physical and biochemical …