Autophagy is essential for the maintenance of cellular homeostasis and its dysfunction has
been linked to various diseases. Autophagy is a membrane driven process and tightly …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the ongoing
coronavirus disease 2019 pandemic. How SARS-CoV-2 regulates cellular responses to …

Autophagosome-lysosome fusion is a common critical step in various forms of
macroautophagy/autophagy including mitophagy, the selective degradation of mitochondria …

Previously, macroautophagy/autophagy was demonstrated to be regulated inter alia by the
primary cilium. Mutations in RPGRIP1L cause ciliary dysfunctions resulting in severe human …

The β-carboline alkaloids are a large group of naturally occurring and synthetic indole
alkaloids with remarkable pharmacological properties. Furthermore, these alkaloids have …

Phosphatidylinositol 3-phosphate (PI (3) P) serves important functions in endocytosis,
phagocytosis, and autophagy. PI (3) P is generated by Vps34 of the class III …

Many members of the poxvirus family are important zoonotic pathogens that pose a
significant threat to human and animal health worldwide. Autophagy is a multi-step …

It was previously shown by our lab that mature phagolysosomes can transiently fuse with the
plasma membrane and release their soluble contents into the extracellular milieu. This …

Obesity and its numerous co-morbid diseases are some of the most common and expensive
health conditions currently facing the developed world. Nonalcoholic fatty liver disease …