The recently-defined four molecular subgroups of medulloblastoma have required updating
of our understanding of in vitro models to include molecular classification and risk …

Traditionally, γ-aminobutyric acid (GABA) is best known for its role as a primary inhibitory
neurotransmitter reducing neuronal excitability in the mammalian central nervous system …

GABA is the most common inhibitory neurotransmitter in the vertebrate central nervous
system. Synthesized by glutamic acid decarboxylase, GABA could specifically bind with two …

Medulloblastoma (MB) is a malignant pediatric brain tumor arising in the cerebellum.
Although abnormal GABAergic receptor activation has been described in MB, studies have …

The nervous system plays a central role in regulating the stem cell niche in many organs,
and thereby pivotally modulates development, homeostasis, and plasticity. A similarly …

Childhood medulloblastomas (MB) are heterogeneous and are divided into four molecular
subgroups. The provisional non-wingless-activated (WNT)/non-sonic hedgehog-activated …

Simple Summary Medulloblastoma is the most common malignant brain tumor in the
pediatric population. Despite the utilization of aggressive treatment modalities, including …

γ-aminobutyric acid or GABA is an amino acid that functionally acts as a neurotransmitter
and is critical to neurotransmission. GABA is also a metabolite in the Krebs cycle. It is …

Abstract Homeobox A5 (HOXA5) is a transcription factor in mammalian and can regulate cell
differentiation, proliferation, and apoptosis as well as tumorigenesis. However, little is known …

Abstract Context Prader-Willi syndrome (PWS) is a complex disorder combining
hypothalamic dysfunction, neurodevelopmental delay, hypotonia, and hyperphagia with risk …