Cancer cells have upregulated glycolysis compared with normal cells, which has led many
to the assumption that oxidative phosphorylation (OXPHOS) is downregulated in all cancers …

Mitochondria are membrane organelles present in almost all eukaryotic cells. In addition to
their well-known role in energy production, mitochondria regulate central cellular processes …

Chronic hyperglycemia causes structural alterations of proteins through the Maillard
reaction. In diabetes, methylglyoxal (MGO)-induced hydroimidazolones are the predominant …

Mitochondria, well recognized as the “powerhouse” of cells, are maternally inherited
organelles with bacterial ancestry that play essential roles in a myriad of cellular functions. It …

Different tissues display distinct sensitivities to defective mitochondrial oxidative
phosphorylation (OXPHOS). Tissues highly dependent on oxygen such as the cardiac …

Objective: Increasing evidence points to the role of mitochondrial dysfunction in the
pathogenesis of sepsis. Previous data indicate that mitochondrial function is affected in …

In the traditional theory of steroid action, steroids bind to intracellular receptors and
modulate nuclear transcription after translocation of steroid–receptor complexes into the …

The Mitchell Theory implies the proton motive force Δp across the inner mitochondrial
membrane as the energy-rich intermediate of oxidative phosphorylation. Δp is composed …

Radiotherapy and chemotherapy are widespread clinical modalities for cancer treatment.
Among other biological influences, hypoxia is a main factor limiting the efficacy of …

Glucocorticoids (GCs) affect most physiological systems and are the most frequently used
drugs for multiple disorders and organ transplantation. GC functions depend on a balance …