This year marks the 25th anniversary of the first Annual Review of Immunology article to
describe features of the T cell antigen receptor (TCR). In celebration of this anniversary, we …

The cellular functions of the actin cytoskeleton require precise regulation of both the
initiation of actin polymerization and the organization of the resulting filaments. The actin …

We identified rare coding variants associated with Alzheimer's disease in a three-stage case–
control study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole …

Cell motility is central to tissue homeostasis in health and disease, and there is hardly any
cell in the body that is not motile at a given point in its life cycle. Important physiological …

Calcium signals in cells of the immune system participate in the regulation of cell
differentiation, gene transcription and effector functions. An increase in intracellular levels of …

Abstract Members of the Wiskott–Aldrich syndrome protein (WASP) family control
cytoskeletal dynamics by promoting actin filament nucleation with the Arp2/3 complex. The …

Actin filaments are major components of at least 15 distinct structures in metazoan cells.
These filaments assemble from a common pool of actin monomers, but do so at different …

The Arp2/3 complex regulates endocytosis, sorting, and trafficking, yet the Arp2/3-stimulating
factors orchestrating these distinct events remain ill defined. WASH (Wiskott-Aldrich …

T cell activation and function require a structured engagement of antigen-presenting cells.
These cell contacts are characterized by two distinct dynamics in vivo: transient contacts …

Immunodeficiency often coincides with hyperactive immune disorders such as autoimmunity,
lymphoproliferation, or atopy, but this coincidence is rarely understood on a molecular level …