Molecular proximity orchestrates biological function, and blocking existing proximities is an
established therapeutic strategy. By contrast, strengthening or creating neoproximity with …

Undruggable proteins are a class of proteins that are often characterized by large, complex
structures or functions that are difficult to interfere with using conventional drug design …

Neurodegenerative diseases (NDs) are currently incurable diseases that cause progressive
degeneration of nerve cells. Many of the disease-causing proteins of NDs are “undruggable” …

Mixed Lineage Kinase domain-Like pseudokinase (MLKL) is implicated in a broad range of
diseases due to its role as the ultimate effector of necroptosis and has therefore emerged as …

Targeted protein degradation (TPD) has emerged as a promising therapeutic approach with
potential advantages over traditional occupancy-based inhibitors in terms of dosing, side …

Metabolic engineering is a powerful tool to reprogramme cells to produce value-added
chemicals. Such engineering strategies require the fine-tuning of a cell's metabolism to …

Targeted protein degradation (TPD), including the use of proteolysis-targeting chimeras
(PROTACs) and molecular glue degraders (MGDs) to degrade proteins, is an emerging …

Tracking gene expression in deep tissues requires genetic reporters that can be
unambiguously detected using tissue penetrant techniques. Magnetic resonance imaging …

This review explores various methods for modulating protein stability to achieve target
protein degradation, which is a crucial aspect in the study of biological processes and drug …

Target validation is key to the development of protein degrading molecules such as
proteolysis‐targeting chimeras (PROTACs) to identify cellular proteins amenable for induced …