Treatments for Alzheimer's disease (AD) directed against the prominent amyloid plaque
neuropathology are yet to be proved effective despite many phase 3 clinical trials. There are …

Oxidative stress is known to play an important role in the pathogenesis of a number of
diseases. In particular, it is linked to the etiology of Alzheimer's disease (AD), an age-related …

Alzheimer's disease (AD) is one of the most common forms of dementia. Despite a wealth of
knowledge on the molecular mechanisms involved in AD, current treatments have mainly …

Copper is an important trace element that is required for essential enzymes. However, due
to its redox activity, copper can also lead to the generation of toxic reactive oxygen species …

Multiple abnormalities occur in the homeostasis of essential endogenous brain biometals in
age-related neurodegenerative disorders, Alzheimer's disease, Parkinson's disease …

Alzheimer's disease is the leading cause of dementia in the elderly and is defined by two
pathological hallmarks; the accumulation of aggregated amyloid beta and excessively …

One of the grand challenges of biophysical chemistry is to understand the principles that
govern protein misfolding and aggregation, which is a highly complex process that is …

The basic role of metal ions including copper, zinc and iron in neurological pathologies is
generally accepted. The relationship between the development of disease and particular …

Copper-transporting ATPases (Cu-ATPases) ATP7A and ATP7B are evolutionarily
conserved polytopic membrane proteins with essential roles in human physiology. The Cu …

There has been steadily growing interest in the participation of metal ions (especially, zinc,
copper, and iron) in neurobiological processes, such as the regulation of synaptic …