[HTML][HTML] Nosocomial pneumonia in 27 ICUs in Europe: perspectives from the EU-VAP/CAP study

D Koulenti, E Tsigou, J Rello - European journal of clinical microbiology & …, 2017 - Springer
We report on intensive care nosocomial pneumonia (NP) in Europe through a review of EU-
VAP/CAP manuscripts: a prospective observational study, enrolling patients from 27 ICUs in …

Antimicrobial resistance in the intensive care unit: a focus on gram-negative bacterial infections

SH MacVane - Journal of intensive care medicine, 2017 - journals.sagepub.com
Bacterial infections are a frequent cause of hospitalization, and nosocomial infections are an
increasingly common condition, particularly within the acute/critical care setting. Infection …

Management of adults with hospital-acquired and ventilator-associated pneumonia: 2016 clinical practice guidelines by the Infectious Diseases Society of America …

AC Kalil, ML Metersky, M Klompas… - Clinical infectious …, 2016 - academic.oup.com
It is important to realize that guidelines cannot always account for individual variation among
patients. They are not intended to supplant physician judgment with respect to particular …

[HTML][HTML] De-escalation of empirical therapy is associated with lower mortality in patients with severe sepsis and septic shock

J Garnacho-Montero, A Gutiérrez-Pizarraya… - Intensive care …, 2014 - Springer
Purposes We set out to assess the safety and the impact on in-hospital and 90-day mortality
of antibiotic de-escalation in patients admitted to the ICU with severe sepsis or septic shock …

Antimicrobial de-escalation in critically ill patients: a position statement from a task force of the European Society of Intensive Care Medicine (ESICM) and European …

A Tabah, M Bassetti, MH Kollef, JR Zahar… - Intensive care …, 2020 - Springer
Background Antimicrobial de-escalation (ADE) is a strategy of antimicrobial stewardship,
aiming at preventing the emergence of antimicrobial resistance (AMR) by decreasing the …

[HTML][HTML] Hospital-acquired pneumonia in ICU

M Leone, L Bouadma, B Bouhemad, O Brissaud… - … Critical Care & Pain …, 2018 - Elsevier
Abstract The French Society of Anesthesia and Intensive Care Medicine and the French
Society of Intensive Care edited guidelines focused on hospital-acquired pneumonia (HAP) …

Antimicrobial resistance: an antimicrobial/diagnostic stewardship and infection prevention approach

EJ Septimus - Medical Clinics, 2018 - medical.theclinics.com
Antimicrobial resistance (AR) is one of the most serious public health threats today, which
has been accelerated by the overuse and misuse of antimicrobials in humans and animals …

Procalcitonin for reduced antibiotic exposure in ventilator-associated pneumonia: a randomised study

D Stolz, N Smyrnios, P Eggimann… - European …, 2009 - Eur Respiratory Soc
In patients with ventilator-associated pneumonia (VAP), guidelines recommend antibiotic
therapy adjustment according to microbiology results after 72 h. Circulating procalcitonin …

Aerosolized antibiotics and ventilator-associated tracheobronchitis in the intensive care unit

LB Palmer, GC Smaldone, JJ Chen, D Baram… - Critical care …, 2008 - journals.lww.com
Objective: The purpose of this study was to determine whether aerosolized antibiotics, which
achieve high drug concentrations in the target organ, would more effectively treat respiratory …

Vaccine protection against Staphylococcus aureus pneumonia

JB Wardenburg, O Schneewind - The Journal of experimental medicine, 2008 - rupress.org
Staphylococcus aureus pneumonia causes significant mortality in hospitalized or healthy
individuals, and recent increases in morbidity are attributed to the rapid spread of methicillin …