Organisms must survive a variety of stressful conditions, including sudden temperature
increases that damage important cellular structures and interfere with essential functions. In …

Cells respond to protein-damaging (proteotoxic) stress by activation of the Heat Shock
Response (HSR). The HSR provides cells with an enhanced ability to endure proteotoxic …

Heat shock proteins (HSPs) are a large family of molecular chaperones aberrantly
expressed in cancer. The expression of HSPs in tumor cells has been shown to be …

Nowadays we understand cell membranes not as a simple double lipid layer but as a
collection of complex and dynamic protein–lipid structures and microdomains that serve as …

• Introduction• Membrane lipid composition• Membrane lipid structure• Membrane lipid
organization‐Why so many different lipids?‐Lipid mixing and demixing‐Lateral pressure …

The protein-and/or lipid-mediated association of chaperone proteins to membranes is a
widespread phenomenon and implicated in a number of physiological and pathological …

Heat stress is a common and, therefore, an important environmental impact on cells and
organisms. While much attention has been paid to severe heat stress, moderate temperature …

Neurodegenerative diseases (NDDs) such as Alzheimer's disease, Parkinson's disease and
Huntington's disease (HD), amyotrophic lateral sclerosis, and prion diseases are all …

Beyond guarding the cellular proteome the major stress inducible heat shock protein Hsp70
has been shown to interact with lipids. Non-cytosolic Hsp70 stabilizes membranes during …

The classic heat shock (stress) response (HSR) was originally attributed to protein
denaturation. However, heat shock protein (Hsp) induction occurs in many circumstances …