▪ Abstract This review provides a synthesis that combines data from classical
experimentation and recent advances in our understanding of early eye development …

Cranial placodes are focal regions of thickened ectoderm in the head of vertebrate embryos
that give rise to a wide variety of cell types, including elements of the paired sense organs …

The molecular mechanisms mediating the retinogenic potential of multipotent retinal
progenitor cells (RPCs) are poorly defined. Prior to initiating retinogenesis, RPCs express a …

Several eye-field transcription factors (EFTFs) are expressed in the anterior region of the
vertebrate neural plate and are essential for eye formation. The Xenopus EFTFs ET, Rx1 …

The tremendous complexity of the adult forebrain makes it a challenging task to elucidate
how this structure forms during embryonic development. Nevertheless, we are beginning to …

Cranial placodes are specialized regions of the ectoderm, which give rise to various sensory
ganglia and contribute to the pituitary gland and sensory organs of the vertebrate head …

Primary open angle glaucoma (POAG) is a complex progressive optic nerve neuropathy
triggered by both environmental and genetic risk factors. Several ocular tissues, including …

The sine oculis homeobox (SIX) protein family is a group of evolutionarily conserved
transcription factors that are found in diverse organisms that range from flatworms to …

The mature eye is a complex organ that develops through a highly organized process during
embryogenesis. Alterations in its genetic programming can lead to severe disorders that …

Recent reports have exposed the temporal and spatial functions of the transcription factor
Pax6 in the developing vertebrate eye. Pax6 is demonstrated to play essential roles in …