The Rab family of small GTPases regulates intracellular membrane trafficking by
orchestrating the biogenesis, transport, tethering, and fusion of membrane‐bound …

The complexity of nanoscale interactions between biomaterials and cells has limited the
realization of the ultimate vision of nanotechnology in diagnostics and therapeutics. As such …

Exosomes are generated within the multivesicular endosomes (MVEs) as intraluminal
vesicles (ILVs) and secreted during the fusion of MVEs with the cell membrane. The …

Eukaryotic cells maintain a highly organized endolysosomal system. This system regulates
the protein and lipid content of the plasma membrane, it participates in the intracellular …

Lysosomes are essential for cellular recycling, nutrient signaling, autophagy, and
pathogenic bacteria and viruses invasion. Lysosomal fusion is fundamental to cell survival …

Membrane traffic in eukaryotic cells is mediated by transport vesicles that bud from a
precursor compartment and are transported to their destination compartment where they …

The compartmentalization of eukaryotic cells is reliant on the fidelity of vesicle-mediated
intracellular transport. Vesicles deliver their cargo via membrane fusion, a process requiring …

Rab molecular switches are key players in defining membrane identity and regulating
intracellular trafficking events in eukaryotic cells. In spite of their global structural similarity …

The key endosomal regulators Rab5, EEA1, and APPL1 are frequently applied in
fluorescence microscopy to mark early endosomes, whereas Rab7 is used as a marker for …

The exocyst is an evolutionarily conserved octameric protein complex that mediates the
tethering of post-Golgi secretory vesicles to the plasma membrane during exocytosis and is …