As a potentially life threatening side effect, pharmaceutical compounds may trigger cardiac
arrhythmias by impeding the heart's electrical and mechanical function. For this reason, any …

The heart is a hierarchical dynamic system consisting of molecules, cells, and tissues, and
acts as a pump for blood circulation. The pumping function depends critically on the …

Mixed-mode oscillations (MMOs) and canards play important role in the dynamics of many
mathematical models in the life sciences. In particular, pathological early …

Human pancreatic beta-cells may exhibit complex mixed-mode oscillatory electrical activity,
which underlies insulin secretion. A recent biophysical model of human beta-cell …

We analyze the dynamical mechanisms underlying the formation of arrhythmogenic early
afterdepolarizations (EADs) in two mathematical models of cardiac cellular …

In this study, we teased out the dynamical mechanisms underlying the generation of
arrhythmogenic early afterdepolarizations (EADs) in a three-variable model of a mammalian …

Arrhythmogenic early afterdepolarizations (EADs) are investigated in a biophysically
detailed mathematical model of a rabbit ventricular myocyte, providing their location in the …

Mathematical models describing the dynamics of the cardiac action potential are of great
value for understanding how changes to the system can disrupt the normal electrical activity …

In recent years, computational cardiac electrophysiology simulations using mathematical
models have begun to be used in industrial and regulatory assessment of the proarrhythmic …

Early afterdepolarizations (EADs) are pathological voltage fluctuations that can occur in
cardiac cells and are a potent source of potentially fatal arrhythmias. Recent works …