DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …

Complex multicellular organisms, such as mammals, express two complete sets of
chromosomes per nucleus, combining the genetic material of both parents. However …

The prevailing views as to the form, function, and regulation of genomic methylation patterns
have their origin many years in the past, at a time when the structure of the mammalian …

In mammals, cytosine methylation is predominantly restricted to CpG dinucleotides and
stably distributed across the genome, with local, cell-type-specific regulation directed by …

The ability to form memories is a prerequisite for an organism's behavioral adaptation to
environmental changes. At the molecular level, the acquisition and maintenance of memory …

DNA methylation is globally reprogrammed during mammalian preimplantation
development, which is critical for normal development. Recent reduced representation …

Differential methylation between the two alleles of a gene has been observed in imprinted
regions, where the methylation of one allele occurs on a parent-of-origin basis, the inactive …

It has been nearly 40 y since it was suggested that genomic methylation patterns could be
transmitted via maintenance methylation during S phase and might play a role in the …

Background Previously, a role was demonstrated for transcription in the acquisition of DNA
methylation at imprinted control regions in oocytes. Definition of the oocyte DNA methylome …

Epigenetic modifications established during gametogenesis regulate transcription and other
nuclear processes in gametes, but also have influences in the zygote, embryo and postnatal …