Autoreactive B cells and interferons are central players in systemic lupus erythematosus
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …

B cells are central to the pathogenesis of multiple autoimmune diseases, through antigen
presentation, cytokine secretion, and the production of autoantibodies. During development …

Augmented T cell function leading to host damage in autoimmunity is supported by
metabolic dysregulation, making targeting immunometabolism an attractive therapeutic …

Systemic Lupus Erythematosus is a complex autoimmune disease and its etiology remains
unknown. Increased gut permeability has been reported in lupus patients, yet whether it …

Introduction Neutrophil extracellular traps (NETs) are web-like structures composed of
nuclear and granular components. The primary role of NETS is to prevent the dissemination …

Autophagy is a highly regulated process wherein an unwanted cargo of damaged and
dysfunctional cytoplasmic components is removed, delivered to lysosomes for degradation …

Nucleic acid autoantibodies, increase type I interferon (IFN-α) levels, and immune cell
hyperactivation are hallmarks of systemic lupus erythematosus (SLE). Notably, immune cell …

Metformin is a first-line therapeutic agent for type 2 diabetes. Apart from its glucose-lowering
effect, metformin is attracting interest regarding possible therapeutic benefits in various other …

Autoimmune diseases (AIDs) refer to connective tissue inflammation caused by aberrant
autoantibodies resulting from dysfunctional immune surveillance. Most of the current …

Pro-inflammatory immune system development, metabolomic defects, and deregulation of
autophagy play interconnected roles in driving the pathogenesis of systemic lupus …