Messenger ribonucleic acid (mRNA)-based drugs, notably mRNA vaccines, have been
widely proven as a promising treatment strategy in immune therapeutics. The extraordinary …

The response of immune cells in cardiac injury is divided into three continuous phases:
inflammation, proliferation and maturation. The kinetics of the inflammatory and proliferation …

Inhaled delivery of mRNA has the potential to treat a wide variety of diseases. However,
nebulized mRNA lipid nanoparticles (LNPs) face several unique challenges including …

In vitro transcribed (IVT) mRNA has recently come into focus as a potential new drug class to
deliver genetic information. Such synthetic mRNA can be engineered to transiently express …

Messenger RNA as a therapeutic modality is becoming increasingly popular in the field of
gene therapy. The realization that nucleobase modifications can greatly enhance the …

Being a transient carrier of genetic information, mRNA could be a versatile, flexible, and safe
means for protein therapies. While recent findings highlight the enormous therapeutic …

Monoclonal antibodies are one of the fastest growing classes of pharmaceutical products,
however, their potential is limited by the high cost of development and manufacturing. Here …

The Cas9/guide RNA (Cas9/gRNA) system is commonly used for genome editing. mRNA
expressing Cas9 can induce innate immune responses, reducing Cas9 expression. First …

In a cell-free approach to regenerative therapeutics, transient application of paracrine factors
in vivo could be used to alter the behavior and fate of progenitor cells to achieve sustained …

Messenger RNAs (mRNAs) were previously shown to have great potential for preventive
vaccination against infectious diseases and therapeutic applications in the treatment of …