The characteristic molecular composition of the different glycosaminoglycans (GAGs) is
related to their role as structural components and regulators of a multitude of functions of …

Direct thrombin inhibitors (DTIs) are a new class of anticoagulants that bind directly to
thrombin and block its interaction with its substrates. Four parenteral DTIs have been …

Glycosaminoglycans, linear carbohydrates such as heparan sulfate and hyaluronan,
participate in a variety of biological processes including cell‐matrix interactions and …

Glycosaminoglycans constitute a considerable fraction of the glycoconjugates found on
cellular membranes and in the extracellular matrix of virtually all mammalian tissues. Their …

The extracellular environment is largely comprised of complex polysaccharides, which were
historically considered inert materials that hydrated the cells and contributed to the structural …

Background Postoperative bleeding is one of the most common complications of cardiac
surgery. Discussion Extensive surgical trauma, prolonged blood contact with the artificial …

A wide range of biomedical devices is applied clinically in contact with blood. Tailoring the
surface properties of the involved biomaterials is a common approach to enhance …

Sulfated α-L-fucans from brown algae (also known as fucoidan) have complex and
heterogeneous structures but recent studies revealed the occurrence of ordered repeat units …

Dabigatran (Pradaxa) is a competitive direct thrombin inhibitor approved by the US FDA for
prevention of embolic stroke in patients with nonvalvular atrial fibrillation. Dabigatran has a …

We attempted to identify the specific structural features in sulfated galactans and sulfated
fucans that confer anticoagulant activity. For this study we employed a variety of invertebrate …