Surface-functionalized nanostructures are at the forefront of biotechnology, providing new
opportunities for biosensors, drug delivery, therapy, and bioimaging applications. The …

Malignant tumors remain a primary cause of human mortality. Among the various treatment
modalities for neoplasms, tumor vaccines have consistently shown efficacy and promising …

Lipid nanoparticles (LNPs) are an essential component of messenger RNA (mRNA)
vaccines and genome editing therapeutics. Ionizable amino lipids, which play the most …

Nucleic acid-based therapies have shown enormous effectiveness as vaccines against the
recent COVID19 pandemics and hold great promises in the fight of a broad spectrum of …

Ionizable lipid-containing lipid nanoparticles (LNPs) have enabled the delivery of RNA for a
range of therapeutic applications. In order to optimize safe, targeted, and effective LNP …

The delivery of mRNA molecules to organs beyond the liver is valuable for therapeutic
applications. Functionalized lipid nanoparticles (LNPs) using exogenous mechanisms can …

The success of mRNA vaccines against COVID-19 has enhanced the potential of lipid
nanoparticles (LNPs) as a system for the delivery of mRNA. In this review, we describe our …

This study employs asymmetric flow field-flow fractionation online coupled with small angle
X-ray scattering at a synchrotron beamline, along with multiple downstream detectors …

I present an automated and flexible tool designed for constructing bilayer membranes at all-
atom (AA) resolution. The builder initiates the construction and equilibration of bilayer …

Since the successful development and application of the COVID-19 mRNA vaccine, lipid
nanoparticle (LNP)-based nucleic acid delivery therapy has received much attention, and …