Alternative animal models of aging research

S Holtze, E Gorshkova, S Braude… - Frontiers in Molecular …, 2021 - frontiersin.org
Most research on mechanisms of aging is being conducted in a very limited number of
classical model species, ie, laboratory mouse (Mus musculus), rat (Rattus norvegicus …

Maturation in Atlantic salmon (Salmo salar, Salmonidae): a synthesis of ecological, genetic, and molecular processes

KB Mobley, T Aykanat, Y Czorlich, A House… - Reviews in Fish Biology …, 2021 - Springer
Over the past decades, Atlantic salmon (Salmo salar, Salmonidae) has emerged as a model
system for sexual maturation research, owing to the high diversity of life history strategies …

Changes in regeneration-responsive enhancers shape regenerative capacities in vertebrates

W Wang, CK Hu, A Zeng, D Alegre, D Hu, K Gotting… - Science, 2020 - science.org
INTRODUCTION The ability to regenerate tissues lost to damage or disease is widely but
nonuniformly distributed in vertebrates. Some animals such as teleost fishes can regenerate …

Animal life history is shaped by the pace of life and the distribution of age-specific mortality and reproduction

K Healy, THG Ezard, OR Jones… - Nature ecology & …, 2019 - nature.com
Animals exhibit an extraordinary diversity of life history strategies. These realized
combinations of survival, development and reproduction are predicted to be constrained by …

Relaxed selection limits lifespan by increasing mutation load

R Cui, T Medeiros, D Willemsen, LNM Iasi, GE Collier… - Cell, 2019 - cell.com
To uncover the selective forces shaping life-history trait evolution across species, we
investigate the genomic basis underlying adaptations to seasonal habitat desiccation in …

[HTML][HTML] Turquoise killifish: A natural model of age-dependent brain degeneration

DEM de Bakker, DR Valenzano - Ageing Research Reviews, 2023 - Elsevier
Turquoise killifish (Nothobranchius furzeri) are naturally short-lived vertebrates that display a
wide range of spontaneous age-related changes, including onset of cancer, reduced …

Nothobranchius furzeri, an 'instant' fish from an ephemeral habitat

M Reichard, M Polačik - Elife, 2019 - elifesciences.org
The turquoise killifish, Nothobranchius furzeri, is a promising vertebrate model in ageing
research and an emerging model organism in genomics, regenerative medicine …

[HTML][HTML] Production of common carp donor-derived offspring from goldfish surrogate broodstock

R Franěk, V Kašpar, MA Shah, D Gela, M Pšenička - Aquaculture, 2021 - Elsevier
Common carp (Cyprinus carpio) is the fourth most-produced species in worldwide
aquaculture. Significant efforts are invested in breeding and preservation of genetic integrity …

A scalable and tunable platform for functional interrogation of peptide hormones in fish

E Moses, R Franek, I Harel - Elife, 2023 - elifesciences.org
Pituitary hormones play a central role in shaping vertebrate life history events, including
growth, reproduction, metabolism, and aging. The regulation of these traits often requires …

The killifish germline regulates longevity and somatic repair in a sex-specific manner

E Moses, T Atlan, X Sun, R Franěk, A Siddiqui… - Nature Aging, 2024 - nature.com
Classical evolutionary theories propose tradeoffs among reproduction, damage repair and
lifespan. However, the specific role of the germline in shaping vertebrate aging remains …