[HTML][HTML] Navigating the complexity of Polycomb repression: Enzymatic cores and regulatory modules
S Tamburri, S Rustichelli, S Amato, D Pasini - Molecular Cell, 2024 - cell.com
Polycomb proteins are a fundamental repressive system that plays crucial developmental
roles by orchestrating cell-type-specific transcription programs that govern cell identity …
roles by orchestrating cell-type-specific transcription programs that govern cell identity …
Intragenic CpG islands and their impact on gene regulation
JA Cain, B Montibus, RJ Oakey - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
The mammalian genome is depleted in CG dinucleotides, except at protected regions where
they cluster as CpG islands (CGIs). CGIs are gene regulatory hubs and serve as …
they cluster as CpG islands (CGIs). CGIs are gene regulatory hubs and serve as …
Systematic identification of factors involved in the silencing of germline genes in mouse embryonic stem cells
H Al Adhami, J Vallet, C Schaal… - Nucleic Acids …, 2023 - academic.oup.com
In mammals, many germline genes are epigenetically repressed to prevent their illegitimate
expression in somatic cells. To advance our understanding of the mechanisms restricting the …
expression in somatic cells. To advance our understanding of the mechanisms restricting the …
Repression of germline genes by PRC1. 6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing
K Mochizuki, J Sharif, K Shirane, K Uranishi… - Nature …, 2021 - nature.com
Silencing of a subset of germline genes is dependent upon DNA methylation (DNAme) post-
implantation. However, these genes are generally hypomethylated in the blastocyst …
implantation. However, these genes are generally hypomethylated in the blastocyst …
Multi- and Transgenerational Effects of Developmental Exposure to Environmental Levels of PFAS and PFAS Mixture in Zebrafish (Danio rerio)
Per-and polyfluoroalkyl substances (PFASs) are ubiquitous in the environment and are tied
to myriad health effects. Despite the phasing out of the manufacturing of two types of PFASs …
to myriad health effects. Despite the phasing out of the manufacturing of two types of PFASs …
[HTML][HTML] Epigenetic mechanisms governing female and male germline development in mammals
K Shirane, M Lorincz - Sexual Development, 2022 - karger.com
Background: DNA methylation (DNAme) and histone posttranslational modifications (PTMs)
play an integral role in the transcriptional regulation of specific sets of genes and …
play an integral role in the transcriptional regulation of specific sets of genes and …
PCGF6 controls neuroectoderm specification of human pluripotent stem cells by activating SOX2 expression
X Lan, S Ding, T Zhang, Y Yi, C Li, W Jin… - Nature …, 2022 - nature.com
Polycomb group (PcG) proteins are known to repress developmental genes during
embryonic development and tissue homeostasis. Here, we report that PCGF6 controls …
embryonic development and tissue homeostasis. Here, we report that PCGF6 controls …
Polycomb repressive complex (es) and their role in adult stem cells
Populations of resident stem cells (SCs) are responsible for maintaining, repairing, and
regenerating adult tissues. In addition to having the capacity to generate all the differentiated …
regenerating adult tissues. In addition to having the capacity to generate all the differentiated …
DNA methylation shapes the polycomb landscape during the exit from naïve pluripotency
J Richard Albert, T Urli… - Nature Structural & …, 2024 - nature.com
Abstract In mammals, 5-methylcytosine (5mC) and Polycomb repressive complex 2 (PRC2)-
deposited histone 3 lysine 27 trimethylation (H3K27me3) are generally mutually exclusive at …
deposited histone 3 lysine 27 trimethylation (H3K27me3) are generally mutually exclusive at …
Histone mono-ubiquitination in transcriptional regulation and its mark on life: emerging roles in tissue development and disease
L Oss-Ronen, T Sarusi, I Cohen - Cells, 2022 - mdpi.com
Epigenetic regulation plays an essential role in driving precise transcriptional programs
during development and homeostasis. Among epigenetic mechanisms, histone mono …
during development and homeostasis. Among epigenetic mechanisms, histone mono …