[HTML][HTML] Navigating the complexity of Polycomb repression: Enzymatic cores and regulatory modules

S Tamburri, S Rustichelli, S Amato, D Pasini - Molecular Cell, 2024 - cell.com
Polycomb proteins are a fundamental repressive system that plays crucial developmental
roles by orchestrating cell-type-specific transcription programs that govern cell identity …

Intragenic CpG islands and their impact on gene regulation

JA Cain, B Montibus, RJ Oakey - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
The mammalian genome is depleted in CG dinucleotides, except at protected regions where
they cluster as CpG islands (CGIs). CGIs are gene regulatory hubs and serve as …

Systematic identification of factors involved in the silencing of germline genes in mouse embryonic stem cells

H Al Adhami, J Vallet, C Schaal… - Nucleic Acids …, 2023 - academic.oup.com
In mammals, many germline genes are epigenetically repressed to prevent their illegitimate
expression in somatic cells. To advance our understanding of the mechanisms restricting the …

Repression of germline genes by PRC1. 6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing

K Mochizuki, J Sharif, K Shirane, K Uranishi… - Nature …, 2021 - nature.com
Silencing of a subset of germline genes is dependent upon DNA methylation (DNAme) post-
implantation. However, these genes are generally hypomethylated in the blastocyst …

Multi- and Transgenerational Effects of Developmental Exposure to Environmental Levels of PFAS and PFAS Mixture in Zebrafish (Danio rerio)

A Haimbaugh, CC Wu, C Akemann, DN Meyer… - Toxics, 2022 - mdpi.com
Per-and polyfluoroalkyl substances (PFASs) are ubiquitous in the environment and are tied
to myriad health effects. Despite the phasing out of the manufacturing of two types of PFASs …

[HTML][HTML] Epigenetic mechanisms governing female and male germline development in mammals

K Shirane, M Lorincz - Sexual Development, 2022 - karger.com
Background: DNA methylation (DNAme) and histone posttranslational modifications (PTMs)
play an integral role in the transcriptional regulation of specific sets of genes and …

PCGF6 controls neuroectoderm specification of human pluripotent stem cells by activating SOX2 expression

X Lan, S Ding, T Zhang, Y Yi, C Li, W Jin… - Nature …, 2022 - nature.com
Polycomb group (PcG) proteins are known to repress developmental genes during
embryonic development and tissue homeostasis. Here, we report that PCGF6 controls …

Polycomb repressive complex (es) and their role in adult stem cells

P Flora, G Dalal, I Cohen, E Ezhkova - Genes, 2021 - mdpi.com
Populations of resident stem cells (SCs) are responsible for maintaining, repairing, and
regenerating adult tissues. In addition to having the capacity to generate all the differentiated …

DNA methylation shapes the polycomb landscape during the exit from naïve pluripotency

J Richard Albert, T Urli… - Nature Structural & …, 2024 - nature.com
Abstract In mammals, 5-methylcytosine (5mC) and Polycomb repressive complex 2 (PRC2)-
deposited histone 3 lysine 27 trimethylation (H3K27me3) are generally mutually exclusive at …

Histone mono-ubiquitination in transcriptional regulation and its mark on life: emerging roles in tissue development and disease

L Oss-Ronen, T Sarusi, I Cohen - Cells, 2022 - mdpi.com
Epigenetic regulation plays an essential role in driving precise transcriptional programs
during development and homeostasis. Among epigenetic mechanisms, histone mono …