Cell invasion into the surrounding extracellular matrix or across tissue boundaries and
endothelial barriers occurs in both physiological and pathological scenarios such as …

The microenvironment encompasses all components of a tumor other than the cancer cells
themselves. It is highly heterogenous, comprising a cellular component that includes …

Cell migration affects all morphogenetic processes and contributes to numerous diseases,
including cancer and cardiovascular disease. For most cells in most environments …

Podosomes and invadopodia are actin-based dynamic protrusions of the plasma membrane
of metazoan cells that represent sites of attachment to—and degradation of—the …

The fusion of myoblasts into multinucleate syncytia plays a fundamental role in muscle
function, as it supports the formation of extended sarcomeric arrays, or myofibrils, within a …

Cells receive extracellular stimuli in various ways: in the form of soluble molecules (growth
factors, cytokines and hormones) that interact with cell-surface receptors; from adhesive …

Actin polymerization and assembly into stress fibers (SFs) is central to many cellular
processes. However, how SFs form in response to the mechanical interaction of cells with …

Atherosclerosis, cancer, and various chronic fibrotic conditions are characterized by an
increase in the migratory behavior of resident cells and the enhanced invasion of assorted …

Cell shape changes underlie a large set of biological processes ranging from cell division to
cell motility. Stereotyped patterns of cell shape changes also determine tissue remodeling …

T cells are mechanosensitive but the effect of stiffness on their functions is still debated. We
characterize herein how human primary CD4+ T cell functions are affected by stiffness within …