The diversity, composition, and function of the bacterial community inhabiting the human
gastrointestinal tract contributes to host health through its role in producing energy or …

Significant interest in recent years has focused on gut microbiota–host interaction because
accumulating evidence has revealed that intestinal microbiota play an important role in …

Conclusions This study demonstrates that E. multilocularis can induce T‐cell exhaustion
through inhibitory receptor TIGIT, and that blocking this checkpoint may reverse the …

Bile acids are signaling molecules that coordinately regulate metabolism and inflammation
via the nuclear farnesoid X receptor (FXR) and the Takeda G protein-coupled receptor 5 …

The efficacy of Roux-en-Y gastric-bypass (RYGB) and other bariatric surgeries in the
management of obesity and type 2 diabetes mellitus and novel developments in …

Bariatric surgery is currently the most effective procedure for the treatment of obesity. Given
the role of the gut microbiota in regulating host metabolism and adiposity, we investigated …

Bariatric surgical procedures, such as vertical sleeve gastrectomy (VSG), are at present the
most effective therapy for the treatment of obesity, and are associated with considerable …

The pathophysiology of obesity and obesity-related diseases such as type 2 diabetes
mellitus (T2DM) is complex and driven by many factors. One of the most recently identified …

The interest in brown adipose tissue (BAT) as a target to combat metabolic disease has
recently been renewed with the discovery of functional BAT in humans. In rodents, BAT can …

Over the past decade, it has become apparent that bile acids are involved in a host of
activities beyond their classic functions in bile formation and fat absorption. The identification …