Abstract The interleukin (IL)-1 family member IL-1α is a ubiquitous and pivotal pro-
inflammatory cytokine. The IL-1α precursor is constitutively present in nearly all cell types in …

Update on the Pathogenesis of Chronic Obstructive Pulmonary Disease | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

Update on Clinical Aspects of Chronic Obstructive Pulmonary Disease | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

Polypharmacy, a common condition among the elderly, is associated with adverse
outcomes, including increased healthcare costs, due to higher mortality, falls and …

The world's population is ageing and an important part of this demographic shift is the
development of chronic illness. In short, a person who does not die of acute illnesses, such …

Anemia of inflammation (AI) is a highly prevalent comorbidity in patients affected by chronic
inflammatory disorders, such as chronic kidney disease, inflammatory bowel disease, or …

Background Because chronic obstructive pulmonary disease (COPD) is a heterogeneous
condition, the identification of specific clinical phenotypes is key to developing more effective …

Background Systemic effects of COPD are incompletely reflected by established prognostic
assessments. We determined the prognostic value of objectively measured physical activity …

Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality
worldwide. Age and smoking are common risk factors for COPD and other illnesses, often …

Comorbidities, are common in COPD, have been associated with poor outcomes and are
thought to relate to systemic inflammation. To investigate comorbidities in relation to …