Fibrosis can affect any organ and is responsible for up to 45% of all deaths in the
industrialized world. It has long been thought to be relentlessly progressive and irreversible …

Liver fibrosis is an advanced liver disease condition, which could progress to cirrhosis and
hepatocellular carcinoma. To date, there is no direct approved antifibrotic therapy, and …

High levels of lactate are positively associated with the prognosis and mortality in patients
with heart attack. Endothelial-to-mesenchymal transition (EndoMT) plays an important role in …

Cardiac fibrosis is mediated by the activation of resident cardiac fibroblasts, which
differentiate into myofibroblasts in response to injury or stress. Although myofibroblast …

Idiopathic pulmonary fibrosis (IPF), the most common form of idiopathic interstitial
pneumonia, is a progressive, irreversible, and typically lethal disease characterized by an …

Diffuse myocardial fibrosis resulting from the excessive deposition of collagen fibres through
the entire myocardium is encountered in a number of chronic cardiac diseases. This lesion …

Fibrosis is the abnormal deposition of extracellular matrix, which can lead to organ
dysfunction, morbidity, and death. The disease burden caused by fibrosis is substantial, and …

Fibrosis is a pathological result of a dysfunctional repair response to tissue injury and occurs
in a number of organs, including the lungs. Cellular metabolism regulates tissue repair and …

Activation of TGF-β1 initiates a program of temporary collagen accumulation important to
wound repair in many organs. However, the outcome of temporary extracellular matrix …

Augmented glycolysis due to metabolic reprogramming in lung myofibroblasts is critical to
their profibrotic phenotype. The primary glycolysis byproduct, lactate, is also secreted into …