Cell-based scaffold-free therapies seek to develop in vitro organotypic three-dimensional
(3D) tissue-like surrogates, capitalising upon the inherent capacity of cells to create tissues …

Twenty years after the initial description of a tissue engineered construct, 3-dimensional
human cardiac tissues of different kinds are now generated routinely in many laboratories …

Engineered human cardiac tissues facilitate progress in regenerative medicine, disease
modelling and drug development. In this Perspective, we reflect on the most notable …

Engineering of three-dimensional (3D) tissues is a promising approach for restoring
diseased or dysfunctional myocardium with a functional replacement. However, a major …

Mesenchymal stem cells (MSCs) have gained increasing attention as a potential approach
for the treatment of bone injuries due to their multi-lineage differentiation potential and also …

In vivo, the interior and exterior of cells is populated by various macromolecules that create
an extremely crowded milieu. Yet again, in vitro eukaryotic cell culture is conducted in dilute …

In recent years, mesenchymal stem cells (MSCs) have been used to improve cardiac
function and attenuate adverse ventricular remodeling of the ischemic myocardium through …

We have developed our original tissue engineering technology “cell sheet engineering”
utilizing temperature-responsive culture dishes. The cells are confluently grown on a …

Cell sheet technology has remained quite popular among tissue engineering techniques
over the last several years. Meanwhile, there is an apparent trend in modern scientific …

Hypertrophic cardiomyopathy (HCM) is a leading cause of sudden cardiac death that often
goes undetected in the general population. HCM is also prevalent in patients with cardio …