Recent pharmacogenomic/pharmacogenetic (PGx) studies have disclosed important roles
for drug transporters in the human body. Changes in the functions of drug transporters due …

Warfarin anticoagulation effect is characterized by marked variability, some of which has
been attributed to CYP2C9 polymorphisms. This study prospectively examines whether a …

The ATP-binding cassette (ABC) transporter superfamily comprises membrane proteins that
translocate a variety of substrates across extra-and intra-cellular membranes, and act as …

Methadone is a mu-opioid receptor agonist used for treating opiate dependence. The range
of effective methadone doses is broad. Part of the large inter-individual variability in efficacy …

Objective Methotrexate (MTX) is a disease-modifying antirheumatic drug used in the
treatment of rheumatoid arthritis (RA). Genetic polymorphisms of reduced folate carrier …

Objective—The purpose of this study was to test the association between polymorphisms in
genes involved in either LDL cholesterol (LDL-C) metabolism or statin pharmacokinetics …

Background and Objective 1, 4‐Dihydropyridine calcium channel blockers, including
amlodipine, are mainly metabolized by cytochrome P450 (CYP) 3A. We investigated the …

В статье отмечается, что индивидуализация медицины-это инновационное
направление, повышающее безопасность и эффективность фармакотерапии …

Pharmacogenomics studies how genes influence a person's response to treatment. When
complex phenotypes are influenced by multiple genetic variations with little effect, a single …

Blood pressure (BP) is a complex trait that is regulated by multiple physiological pathways
and include but is not limited to extracellular fluid volume homeostasis, cardiac contractility …