With the world's population ageing, the incidence of Parkinson's disease (PD) is on the rise.
In recent years, inflammatory processes have emerged as prominent contributors to the …

During aging, the cellular milieu of the brain exhibits tell-tale signs of compromised
bioenergetics, impaired adaptive neuroplasticity and resilience, aberrant neuronal network …

Loss of functional mitochondrial complex I (MCI) in the dopaminergic neurons of the
substantia nigra is a hallmark of Parkinson's disease. Yet, whether this change contributes to …

Parkinson's disease (PD) is a heterogeneous neurodegenerative disorder that affects an
estimated 10 million sufferers worldwide. The two forms of PD include familial and sporadic …

Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Intracellular α-synuclein (α-syn)-rich protein aggregates called Lewy pathology (LP) and
neuronal death are commonly found in the brains of patients with clinical Parkinson disease …

Although the pathogenesis of neurodegenerative diseases is still widely unclear, various
mechanisms have been proposed and several pieces of evidence are supportive for an …

Circular RNA s (circ RNA s) are brain‐abundant RNA s of mostly unknown functions. To
seek their roles in Parkinson's disease (PD), we generated an RNA sequencing resource of …

Oxidative stress plays an important role in the degeneration of dopaminergic neurons in
Parkinson's disease (PD). Disruptions in the physiologic maintenance of the redox potential …

Background Intraneuronal α-synuclein (α-Syn) aggregates known as Lewy bodies (LBs) and
the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) are the …