Osteoarthritis: pathogenic signaling pathways and therapeutic targets

Q Yao, X Wu, C Tao, W Gong, M Chen, M Qu… - Signal transduction and …, 2023 - nature.com
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …

[HTML][HTML] Epidemiology of osteoarthritis

KD Allen, LM Thoma, YM Golightly - Osteoarthritis and cartilage, 2022 - Elsevier
Objective To summarize the current state of the evidence regarding osteoarthritis (OA)
prevalence, incidence and risk factors at the person-level and joint-level. Design This was a …

Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies

A Cui, H Li, D Wang, J Zhong, Y Chen, H Lu - EClinicalMedicine, 2020 - thelancet.com
Background Knee osteoarthritis (OA) is a major cause of disability in the elderly, however,
there are few studies to estimate the global prevalence, incidence, and risk factors of knee …

The burden of osteoarthritis: Is it a rising problem?

WJ Scheuing, AM Reginato, M Deeb… - Best Practice & Research …, 2023 - Elsevier
The objective of this review is to provide an overview of the current status of osteoarthritis
(OA) as one of the most common joint disorders worldwide. Despite being the 11th cause of …

Prevalence and incidence of osteoarthritis: a population-based retrospective cohort study

R Hamood, M Tirosh, N Fallach, G Chodick… - Journal of clinical …, 2021 - mdpi.com
While trends data of osteoarthritis (OA) are accumulating, primarily from Western Europe
and the US, a gap persists in the knowledge of OA epidemiology in Middle Eastern …

Bidirectional relationship between osteoarthritis and periodontitis: a population-based cohort study over a 15-year follow-up

KSK Ma, JN Lai, E Thota, HT Yip, NC Chin… - Frontiers in …, 2022 - frontiersin.org
Objective To identify the relationship between osteoarthritis and periodontitis. Methods
144,788 periodontitis patients and 144,788 propensity score-matched controls without …

Data-driven identification of predictive risk biomarkers for subgroups of osteoarthritis using interpretable machine learning

RL Nielsen, T Monfeuga, RR Kitchen, L Egerod… - Nature …, 2024 - nature.com
Osteoarthritis (OA) is increasing in prevalence and has a severe impact on patients' lives.
However, our understanding of biomarkers driving OA risk remains limited. We developed a …

The burden of osteoarthritis due to high Body Mass Index in Iran from 1990 to 2019

M Darbandi, FK Shadmani, M Miryan, M Ghalandari… - Scientific Reports, 2023 - nature.com
High BMI related burden of knee and hip osteoarthritis (OA) is on a significant rise
worldwide. OA not only causes joint pain and stiffness, but it also leads to disability. This …

Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting

S Swain, C Coupland, C Mallen, CF Kuo… - …, 2021 - academic.oup.com
Objective To determine the burden of comorbidities in OA and their temporal relationships in
the UK. Methods The Clinical Practice Research Datalink (CPRD) GOLD was used to …

Prevalence and incidence of neuromuscular conditions in the UK between 2000 and 2019: a retrospective study using primary care data

IM Carey, E Banchoff, N Nirmalananthan, T Harris… - PLoS …, 2021 - journals.plos.org
Background In the UK, large-scale electronic primary care datasets can provide up-to-date,
accurate epidemiological information on rarer diseases, where specialist diagnoses from …