Recent update on the heterogeneity of the Alzheimer's disease spectrum

KA Jellinger - Journal of Neural Transmission, 2022 - Springer
Abstract Alzheimer's disease (AD), the most common form of dementia worldwide, is a mixed
proteinopathy (β-amyloid, tau and other proteins). Classically defined as a …

The heterogeneity of late-life depression and its pathobiology: a brain network dysfunction disorder

KA Jellinger - Journal of Neural Transmission, 2023 - Springer
Depression is frequent in older individuals and is often associated with cognitive impairment
and increasing risk of subsequent dementia. Late-life depression (LLD) has a negative …

Understanding the lived experiences of family caregivers of individuals with dementia in Soweto, a South African Township

A Mahomed, C Pretorius - Dementia, 2022 - journals.sagepub.com
This study was undertaken to understand South African family caregivers' lived experiences
of individuals living with dementia in a predominantly Black African township. A …

Characterization of apathy-like behaviors in the 5xFAD mouse model of Alzheimer's disease

R Keszycki, G Rodriguez, JT Dunn, A Locci… - Neurobiology of …, 2023 - Elsevier
Most patients with Alzheimer's disease (AD) develop neuropsychiatric symptoms (NPS)
alongside cognitive decline, and apathy is one of the most common symptoms. Few …

Informant-rated change in personality traits, psychological distress, well-being, and social connection with dementia

AR Sutin, M Luchetti, Y Stephan… - Archives of Gerontology …, 2023 - Elsevier
Objectives Studies of retrospective personality change with dementia consistently find
caregivers report large changes in personality (eg, increases in neuroticism) of their care …

The Impact of Rhythmic Physical Activity on Mental Health and Quality of Life in Older Adults with and without Cognitive Impairment: A Systematic Review and Meta …

M Sanchez-Alcala, A Aibar-Almazan… - Journal of Clinical …, 2023 - mdpi.com
(1) Background: Nowadays, it is essential to implement new non-pharmacological
strategies, such as rhythmic physical activity, to improve mental health and quality of life in …

Specific agitation behaviours in dementia differentially contribute to aspects of caregiver burden

KS Patrick, J Gunstad, JT Martin, KR Chapman… - …, 2022 - Wiley Online Library
Background Agitation is a common symptom in dementia and linked to caregiver burden, but
both agitation and burden are multidimensional constructs. The current study sought to …

Dyadic Ambivalence in Couples Managing Early-Stage Alzheimer's Disease: Linking Behavioral and Psychological Symptoms of Dementia to Life Satisfaction

M Huo, M Gilligan, K Kim, NE Richards… - The Journals of …, 2024 - academic.oup.com
Objectives Caring for a spouse with Alzheimer's disease (AD) can elicit considerable
distress but there are also positive moments. A growing body of work has examined …

Neuropsychiatric symptoms as a prodromal factor in Alzheimer's type neurodegenerative disease: A scoping review

DA Ferreira, LBC Macedo, MP Foss - The Clinical …, 2024 - Taylor & Francis
Objective: Identifying neuropsychiatric symptoms (NPS) can aid in the early detection of
Alzheimer's disease (AD); however, there is still a need for a greater consensus. This review …

The reporting of neuropsychiatric symptoms in electronic health records of individuals with Alzheimer's disease: a natural language processing study

WS Eikelboom, EH Singleton, E van den Berg… - Alzheimer's Research & …, 2023 - Springer
Background Neuropsychiatric symptoms (NPS) are prevalent in the early clinical stages of
Alzheimer's disease (AD) according to proxy-based instruments. Little is known about which …