The role of m6A RNA methylation in cancer metabolism
Y An, H Duan - Molecular cancer, 2022 - Springer
Metabolic reprogramming is one of the main characteristics of malignant tumors, which is
due to the flexible changes of cell metabolism that can meet the needs of cell growth and …
due to the flexible changes of cell metabolism that can meet the needs of cell growth and …
The updated landscape of tumor microenvironment and drug repurposing
Accumulating evidence shows that cellular and acellular components in tumor
microenvironment (TME) can reprogram tumor initiation, growth, invasion, metastasis, and …
microenvironment (TME) can reprogram tumor initiation, growth, invasion, metastasis, and …
Peroxidase-like active nanomedicine with dual glutathione depletion property to restore oxaliplatin chemosensitivity and promote programmed cell death
F Wu, Y Du, J Yang, B Shao, Z Mi, Y Yao, Y Cui, F He… - ACS …, 2022 - ACS Publications
The nanocatalytic activity of nanozymes provides a vision for tumor treatment. However, the
glutathione (GSH)-related antioxidant defense system (ADS) formed on the basis of …
glutathione (GSH)-related antioxidant defense system (ADS) formed on the basis of …
The Warburg effect: essential part of metabolic reprogramming and central contributor to cancer progression
P Vaupel, H Schmidberger, A Mayer - International journal of …, 2019 - Taylor & Francis
In the early 1920s, Warburg published experimental data on the enhanced conversion of
glucose to pyruvate (followed by lactate formation) even in the presence of abundant oxygen …
glucose to pyruvate (followed by lactate formation) even in the presence of abundant oxygen …
The metabolic mechanisms of breast cancer metastasis
L Wang, S Zhang, X Wang - Frontiers in Oncology, 2021 - frontiersin.org
Breast cancer is one of the most common malignancy among women worldwide. Metastasis
is mainly responsible for treatment failure and is the cause of most breast cancer deaths …
is mainly responsible for treatment failure and is the cause of most breast cancer deaths …
Targeting carbonic anhydrase IX and XII isoforms with small molecule inhibitors and monoclonal antibodies
Carbonic anhydrases IX and CAXII (CAIX/CAXII) are transmembrane zinc metalloproteins
that catalyze a very basic but crucial physiological reaction: the conversion of carbon dioxide …
that catalyze a very basic but crucial physiological reaction: the conversion of carbon dioxide …
Crosstalk among m6A RNA methylation, hypoxia and metabolic reprogramming in TME: from immunosuppressive microenvironment to clinical application
F Zhang, H Liu, M Duan, G Wang, Z Zhang… - Journal of hematology & …, 2022 - Springer
The tumor microenvironment (TME), which is regulated by intrinsic oncogenic mechanisms
and epigenetic modifications, has become a research hotspot in recent years. Characteristic …
and epigenetic modifications, has become a research hotspot in recent years. Characteristic …
Targeting tumor-intrinsic hexosamine biosynthesis sensitizes pancreatic cancer to anti-PD1 therapy
Pancreatic ductal adenocarcinoma (PDAC) is considered to be a highly immunosuppressive
and heterogenous neoplasm. Despite improved knowledge regarding the genetic …
and heterogenous neoplasm. Despite improved knowledge regarding the genetic …
Integration of Hippo-YAP signaling with metabolism
The Hippo-Yes-associated protein (YAP) signaling network plays a central role as an
integrator of signals that control cellular proliferation and differentiation. The past several …
integrator of signals that control cellular proliferation and differentiation. The past several …
Ketogenic diet in cancer prevention and therapy: molecular targets and therapeutic opportunities
Although cancer is still one of the most significant global challenges facing public health, the
world still lacks complementary approaches that would significantly enhance the efficacy of …
world still lacks complementary approaches that would significantly enhance the efficacy of …