Lipid metabolism and signaling in cardiac lipotoxicity
K D'Souza, C Nzirorera, PC Kienesberger - Biochimica et Biophysica Acta …, 2016 - Elsevier
The heart balances uptake, metabolism and oxidation of fatty acids (FAs) to maintain ATP
production, membrane biosynthesis and lipid signaling. Under conditions where FA uptake …
production, membrane biosynthesis and lipid signaling. Under conditions where FA uptake …
Reverse remodeling in heart failure—mechanisms and therapeutic opportunities
N Koitabashi, DA Kass - Nature Reviews Cardiology, 2012 - nature.com
Heart failure (HF) involves changes in cardiac structure, myocardial composition, myocyte
deformation, and multiple biochemical and molecular alterations that impact heart function …
deformation, and multiple biochemical and molecular alterations that impact heart function …
Protein kinase C in heart failure: a therapeutic target?
SS Palaniyandi, L Sun, JCB Ferreira… - Cardiovascular …, 2009 - academic.oup.com
Heart failure (HF) afflicts about 5 million people and causes 300 000 deaths a year in the
United States alone. An integral part of the pathogenesis of HF is cardiac remodelling, and …
United States alone. An integral part of the pathogenesis of HF is cardiac remodelling, and …
Protein kinase C and cardiac dysfunction: a review
RM Singh, E Cummings, C Pantos, J Singh - Heart failure reviews, 2017 - Springer
Heart failure (HF) is a physiological state in which cardiac output is insufficient to meet the
needs of the body. It is a clinical syndrome characterized by impaired ability of the left …
needs of the body. It is a clinical syndrome characterized by impaired ability of the left …
Mechanisms for redox-regulation of protein kinase C
SF Steinberg - Frontiers in Pharmacology, 2015 - frontiersin.org
Protein kinase C (PKC) is comprised of a family of signal-regulated enzymes that play
pleiotropic roles in the control of many physiological and pathological responses. PKC …
pleiotropic roles in the control of many physiological and pathological responses. PKC …
Protein kinase C (PKC) isozymes and cancer
JH Kang - New Journal of Science, 2014 - Wiley Online Library
Protein kinase C (PKC) is a family of phospholipid‐dependent serine/threonine kinases,
which can be further classified into three PKC isozymes subfamilies: conventional or classic …
which can be further classified into three PKC isozymes subfamilies: conventional or classic …
Protein kinase C and toll‐like receptor signaling
DJ Loegering, MR Lennartz - Enzyme research, 2011 - Wiley Online Library
Protein kinase C (PKC) is a family of kinases that are implicated in a plethora of diseases,
including cancer and cardiovascular disease. PKC isoforms can have different, and …
including cancer and cardiovascular disease. PKC isoforms can have different, and …
Protein kinase C-α and the regulation of diverse cell responses
Protein kinase C (PKC) comprises a family of lipid-sensitive enzymes that have been
involved in a broad range of cellular functions. PKC-α is a member of classical PKC with …
involved in a broad range of cellular functions. PKC-α is a member of classical PKC with …
Apelin increases cardiac contractility via protein kinase Cε-and extracellular signal-regulated kinase-dependent mechanisms
A Perjes, R Skoumal, O Tenhunen, A Konyi, M Simon… - PloS one, 2014 - journals.plos.org
Background Apelin, the endogenous ligand for the G protein-coupled apelin receptor, is an
important regulator of the cardiovascular homoeostasis. We previously demonstrated that …
important regulator of the cardiovascular homoeostasis. We previously demonstrated that …
Dynamics and membrane interactions of protein kinase C
TI Igumenova - Biochemistry, 2015 - ACS Publications
Protein kinase C (PKC) is a family of Ser/Thr kinases that regulate a multitude of cellular
processes through participation in the phosphoinositide signaling pathway. Significant …
processes through participation in the phosphoinositide signaling pathway. Significant …