BACKGROUND As the world population ages, chronic diseases such as diabetes,
cardiovascular disease, cancer, and neurodegeneration become ever more prevalent …

Aging involves the systemic deterioration of all known cell types in most eukaryotes. Several
recently discovered compounds that extend the healthspan and lifespan of model organisms …

Protein fermentation by gut microbiota contributes significantly to the metabolite pool in the
large intestine and may contribute to host amino acid balance. However, we have a limited …

Background Spermidine administration is linked to increased survival in several animal
models. Objective The aim of this study was to test the potential association between …

Polyamines are essential for the proliferation, differentiation, and development of
eukaryotes. They include spermine, spermidine, and the diamine precursor putrescine, and …

The polyamines putrescine, spermidine, and spermine are widely distributed polycationic
compounds essential for cellular functions. Intracellular polyamine pools are tightly …

The human diet and dietary patterns are closely linked to the health status. High-calorie
Western-style diets have increasingly come under scrutiny as their caloric load and …

Background & Aims Because inflammatory bowel disease is increasing worldwide and can
lead to colitis-associated carcinoma (CAC), new interventions are needed. We have shown …

Natural polyamines (spermidine and spermine) are small, positively charged molecules that
are ubiquitously found within organisms and cells. They exert numerous (intra) cellular …

Polyamines, spermidine and spermine, are synthesized in every living cell and are therefore
contained in foods, especially in those that are thought to contribute to health and longevity …