Massively parallel sequencing: the next big thing in genetic medicine
T Tucker, M Marra, JM Friedman - The American Journal of Human …, 2009 - cell.com
Massively parallel sequencing has reduced the cost and increased the throughput of
genomic sequencing by more than three orders of magnitude, and it seems likely that costs …
genomic sequencing by more than three orders of magnitude, and it seems likely that costs …
Canonical genetic signatures of the adult human brain
The structure and function of the human brain are highly stereotyped, implying a conserved
molecular program responsible for its development, cellular structure and function. We …
molecular program responsible for its development, cellular structure and function. We …
Molecular genetics of obsessive–compulsive disorder: a comprehensive meta-analysis of genetic association studies
S Taylor - Molecular psychiatry, 2013 - nature.com
Twin studies indicate that obsessive–compulsive disorder (OCD) is strongly influenced by
additive genetic factors. Yet, molecular genetic association studies have yielded inconsistent …
additive genetic factors. Yet, molecular genetic association studies have yielded inconsistent …
Multivariate analysis reveals genetic associations of the resting default mode network in psychotic bipolar disorder and schizophrenia
SA Meda, G Ruaño, A Windemuth… - Proceedings of the …, 2014 - National Acad Sciences
The brain's default mode network (DMN) is highly heritable and is compromised in a variety
of psychiatric disorders. However, genetic control over the DMN in schizophrenia (SZ) and …
of psychiatric disorders. However, genetic control over the DMN in schizophrenia (SZ) and …
Neurovascular unit dysfunction with blood-brain barrier hyperpermeability contributes to major depressive disorder: a review of clinical and experimental evidence
S Najjar, DM Pearlman, O Devinsky, A Najjar… - Journal of …, 2013 - Springer
About one-third of people with major depressive disorder (MDD) fail at least two
antidepressant drug trials at 1 year. Together with clinical and experimental evidence …
antidepressant drug trials at 1 year. Together with clinical and experimental evidence …
Co‐shared genetics and possible risk gene pathway partially explain the comorbidity of schizophrenia, major depressive disorder, type 2 diabetes, and metabolic …
TT Postolache, L del Bosque‐Plata… - American Journal of …, 2019 - Wiley Online Library
Schizophrenia (SCZ) and major depressive disorder (MDD) in treatment‐naive patients are
associated with increased risk for type 2 diabetes (T2D) and metabolic syndrome (MetS) …
associated with increased risk for type 2 diabetes (T2D) and metabolic syndrome (MetS) …
Palmitoylation by DHHC5/8 targets GRIP1 to dendritic endosomes to regulate AMPA-R trafficking
Palmitoylation, a key regulatory mechanism controlling protein targeting, is catalyzed by
DHHC-family palmitoyl acyltransferases (PATs). Impaired PAT activity is linked to …
DHHC-family palmitoyl acyltransferases (PATs). Impaired PAT activity is linked to …
A genome‐wide association study identifies multiple loci associated with mathematics ability and disability
SJ Docherty, OSP Davis, Y Kovas… - Genes, Brain and …, 2010 - Wiley Online Library
Numeracy is as important as literacy and exhibits a similar frequency of disability. Although
its etiology is relatively poorly understood, quantitative genetic research has demonstrated …
its etiology is relatively poorly understood, quantitative genetic research has demonstrated …
Trastorno depresivo, trastorno de ansiedad y dolor crónico: múltiples manifestaciones de un núcleo fisiopatológico y clínico común
CA Arango-Dávila, HG Rincón-Hoyos - Revista colombiana de Psiquiatría, 2018 - Elsevier
Introducción Una alta proporción de los trastornos depresivos se acompañan de
manifestaciones ansiosas, así como la depresión y la ansiedad cursan frecuentemente con …
manifestaciones ansiosas, así como la depresión y la ansiedad cursan frecuentemente con …
Candidate genes in panic disorder: meta-analyses of 23 common variants in major anxiogenic pathways
AS Howe, HN Buttenschøn, A Bani-Fatemi… - Molecular …, 2016 - nature.com
The utilization of molecular genetics approaches in examination of panic disorder (PD) has
implicated several variants as potential susceptibility factors for panicogenesis. However …
implicated several variants as potential susceptibility factors for panicogenesis. However …